随着腹腔镜胰十二指肠切除术技术水平的进步与发展，有效防治术后胰瘘和出血成为提高该术式安全性的关键。腹腔镜胰十二指肠切除术后胰瘘和出血的预防应当贯穿于整个围术期，通过充分术前评估，调整术前状态，术中精细操作，选择合适的吻合及引流方式，合理用药及术后密切监测等进行综合预防。对术后胰瘘和出血采取及时有效的处理措施，包括保持引流通畅，控制感染，加强营养和选择合理的干预时机与方式等，通过多学科联合治疗使患者最大程度获益。

With the rapid development of laparoscopic pancreaticoduodenectomy, effective prevention and treatment of postoperative pancreatic fistula and bleeding has become the key to improve the safety of laparoscopic pancreaticoduodenectomy. The prevention of pancreatic fistula and bleeding after pancreaticoduodenectomy should run through the perioperative period. Comprehensive prevention should be carried out by full preoperative evaluation, adjustment of preoperative state, fine intraoperative operation, selection of appropriate anastomosis and drainage, rational use of drugs and close monitoring. Timely and effective measures should be taken to deal with postoperative pancreatic fistula and postoperative bleeding, including keeping drainage smooth, controlling infection, strengthening nutrition and choosing reasonable timing and method of intervention, so as to maximize the benefit of patients through multidisciplinary combined treatment.