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中华普外科手术学杂志(电子版) ›› 2020, Vol. 14 ›› Issue (06) : 604 -607. doi: 10.3877/cma.j.issn.1674-3946.2020.06.020

所属专题: 经典病例 经典病例 文献

论著

208例T1-2N1M0期乳腺癌改良根治术患者无病生存情况的危险因素分析
梁国刚1, 高薇丽1, 王群先1,(), 林丽丽1, 王豆豆1   
  1. 1. 266000 青岛,青岛市第八人民医院
  • 收稿日期:2019-12-26 出版日期:2020-12-26
  • 通信作者: 王群先

Risk factors analysis of Disease-Free Survival after modified radical mastectomy in 208 patients with T1-2N1M0 breast cancer

Guogang Liang1, Weili Gao1, Qunxian Wang1,(), Lili Lin1, Doudou Wang1   

  1. 1. The 8th People's Hospital of Qingdao City, Shandong 266000, China
  • Received:2019-12-26 Published:2020-12-26
  • Corresponding author: Qunxian Wang
  • About author:
    Corresponding author: Wang Qunxian, Email:
  • Supported by:
    Key R & D Program of Shandong Science and Technology Department(2015JM028)
引用本文:

梁国刚, 高薇丽, 王群先, 林丽丽, 王豆豆. 208例T1-2N1M0期乳腺癌改良根治术患者无病生存情况的危险因素分析[J/OL]. 中华普外科手术学杂志(电子版), 2020, 14(06): 604-607.

Guogang Liang, Weili Gao, Qunxian Wang, Lili Lin, Doudou Wang. Risk factors analysis of Disease-Free Survival after modified radical mastectomy in 208 patients with T1-2N1M0 breast cancer[J/OL]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2020, 14(06): 604-607.

目的

探究行改良根治术的T1-2N1M0期乳腺癌患者无病生存的影响因素。

方法

回顾性分析2011年1月至2014年11月经改良根治术治疗208例T1-2N1M0期乳腺癌患者资料,统计术后截止2019年11月患者随访情况,并记录患者术后5年肿瘤转移、复发情况,以SPSS 22.00统计学软件进行数据处理。计数资料用[例(%)]表示,组间比较采用χ2检验;乳腺癌患者预后的相关因素行单因素和Cox多因素回归模型分析,P<0.05差异有统计学意义。

结果

本次研究中208例患者均获得确切随访,无失访病例。其中复发、转移28例(13.5%),无转移复发180例(86.5%),患者5年无病生存率为86.5%;将单因素分析结果具有统计学意义的变量纳入Cox多因素回归模型。结果显示,年龄<45岁、组织学分级为III级、术后放疗、Ki-6 ≥30%为行改良根治术T1-2N1M0期乳腺癌患者复发转移的独立预后因素(P<0.05)。

结论

年龄<45岁、组织学分级为III级、术后放疗、Ki-67≥30%是T1-2N1M0期乳腺癌患者行改良根治术后复发转移的独立危险因素,增加患者预后风险。

Objective

To investigate the risk factors of disease-free survival rate after modified radical mastectomy in patients with T1-2N1M0 stage breast cancer.

Methods

Retrospective analysis were performed in 208 patients with T1-2N1M0 breast cancer underwent modified radical mastectomy from January 2011 to November 2014. The endpoint of follow-up was November 2019 and 5-years survival, of patients metastasis and recurrence of tumors were analyzed, Statistical analysis were performed by using SPSS 22.0 software. Count data were expressed as % and were analyzed by using χ2 test. The univariate and Cox multivariate regression models were used to analyze the risk factors of prognosis. A P value<0.05 was considered as statistically significant difference.

Results

In this study, 208 patients were followed up. Among them, 28 cases had metastatic or recurrence, 180 cases had no metastasis and recurrence, with the 5-year disease-free survival rate of 86.5%. The results of single factor analysis showed that the risk factors of prognosis of patients with T1-2N1M0 breast cancer undergoing modified radical mastectomy included age of <45, Histological grade III, postoperative radiotherapy and Ki-67≥30%, with statistically significant difference (P<0.05).

Conclusion

Age of <45y, histological grade III, postoperative radiotherapy and Ki-67≥30% are independent risk factors for recurrence and metastasis after modified radical mastectomy in patients with T1-2N1M0 stage breast cancer, which might increase the prognosis risk.

表1 208例T1-2N1M0期乳腺癌患者行改良根治术预后的单因素分析[例(%)]
表2 影响行改良根治术T1-2N1M0期乳腺癌患者预后的Cox多因素分析
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