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中华普外科手术学杂志(电子版) ›› 2020, Vol. 14 ›› Issue (06) : 608 -611. doi: 10.3877/cma.j.issn.1674-3946.2020.06.021

所属专题: 文献

论著

保留乳头乳晕复合体的乳腺癌改良根治术预后的相关因素分析
李福平1, 王茂1, 刘超2, 李宏1, 宫小勇1, 周志辉1, 李媛媛1, 代引海1,()   
  1. 1. 712000 陕西咸阳,陕西中医药大学第二附属医院肿瘤乳腺科
    2. 712000 陕西咸阳,陕西中医药大学第二附属医院肿瘤乳腺科;111000 辽宁辽阳,辽阳市中心医院普外二科
  • 收稿日期:2020-02-21 出版日期:2020-12-26
  • 通信作者: 代引海

Correlation analysis of prognostic factors in modified radical mastectomy for breast cancer with preserved papillary areola complex

Fuping Li1, Mao Wang1, Chao Liu2, Hong Li1, Xiaoyong Gong1, Zhihui Zhou1, Yuanyuan Li1, Yinhai Dai1,()   

  1. 1. Department of breast cancer, the second affiliated hospital of shaanxi university of traditional Chinese medicine, XianYang 712000
    2. Department of breast cancer, the second affiliated hospital of shaanxi university of traditional Chinese medicine, XianYang 712000; Liaoyang central hospital two general department, Liaoyang 111000
  • Received:2020-02-21 Published:2020-12-26
  • Corresponding author: Yinhai Dai
  • About author:
    Corresponding author: Dai Yinhai, Email:
  • Supported by:
    Key research and development plan of liaoning provincial department of science and technology(2016JM137); Discipline innovation team project of shaanxi university of traditional Chinese medicine(2019-SY03)
引用本文:

李福平, 王茂, 刘超, 李宏, 宫小勇, 周志辉, 李媛媛, 代引海. 保留乳头乳晕复合体的乳腺癌改良根治术预后的相关因素分析[J/OL]. 中华普外科手术学杂志(电子版), 2020, 14(06): 608-611.

Fuping Li, Mao Wang, Chao Liu, Hong Li, Xiaoyong Gong, Zhihui Zhou, Yuanyuan Li, Yinhai Dai. Correlation analysis of prognostic factors in modified radical mastectomy for breast cancer with preserved papillary areola complex[J/OL]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2020, 14(06): 608-611.

目的

探究影响保留乳头乳晕复合体(NAC)的乳腺癌改良根治术(NSM)预后的相关因素。

方法

回顾性分析2011年1月至2014年12月84例早期原发性乳腺癌并接受NAC的NSM患者临床病理资料。使用统计软件SPSS 20.0进行数据分析,采用K-M生存曲线评估术后无病生存(DFS)及总生存(OS),采用单因素分析和Cox多因素分析影响NSM术后患者DFS和OPS的影响因素。P<0.05差异有统计学意义。

结果

术后局部复发8例,远处转移6例,术后5年DFS为83.3%,OS为91.7%。多因素分析显示,肿瘤最大径、肿瘤距乳头乳晕距离(TND)、腋窝淋巴结状态、组织学类型及Her-2阳性是影响DFS的独立危险因素(P<0.05);而腋窝淋巴结状态是影响术后OS的独立危险因素(P<0.05)。

结论

肿瘤最大径、TND、腋窝淋巴结状态、组织学类型及Her-2阳性是DFS的独立危险因素,腋窝淋巴结状态是OS的独立危险因素;腋窝淋巴结情况同时影响患者术后DFS和OS,术前系统、精准地评估并妥善处理特殊腋窝淋巴结可提高乳腺癌患者预后。

Objective

To explore the factors influencing the prognosis of modified radical mastectomy (NSM) for breast cancer with preserved papillary areola complex.

Methods

A retrospective analysis was performed on the clinicopathological data of 84 patients with early primary breast cancer who underwent NAC retention modified radical mastectomy from January 2011 to December 2014. Postoperative recurrence and metastasis were observed, data entry was analyzed using statistical software SPSS 20.0, and postoperative disease-free survival (DFS) and overall survival (OS) were evaluated using K-M survival curve.K-M univariate analysis and Cox multivariate analysis were used to explore the influencing factors on DFS and OPS of patients after NSM surgery.

Results

Postoperative local recurrence was found in 8 cases and distant metastasis in 6 cases. The 5-year survival curve of K-M was 83.3% for DFS and 91.7% for OS. Multivariate analysis showed that maximum tumor diameter, tumor distance from the nipple and areola (TND), axillary lymph node status, histological type and positive Her-2 were independent risk factors affecting DFS (P<0.05); Axillary lymph node status was an independent risk factor for postoperative OS (P<0.05).

Conclusion

Maximum tumor diameter, TND, axillary lymph node status, histological type and positive Her-2 were independent risk factors for DFS, while axillary lymph node status was an independent risk factor for OS. The status of axillary lymph nodes affects both postoperative DFS and OS, and preoperative systematic, accurate evaluation and proper treatment of special axillary lymph nodes can improve the prognosis of breast cancer patients.

表1 84例早期原发性乳腺癌患者的临床病理特征
表2 早期原发性乳腺癌患者术后5年DFS及OS的Kaplan-Meier单因素分析
表3 影响早期原发性乳腺癌患者术后DFS的Cox多因素分析
表4 影响早期原发性乳腺癌患者术后OS的Cox多因素分析
图1 84例早期原发性乳腺癌患者术后5年DFS和OS生存曲线
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