To compare the effects of early laparoscopic cholecystectomy (LC) and percutaneous hepatic puncture biliary drainage (PTCD) on liver function and prognosis of patients with acute cholecystitis.

A total of 92 patients with acute cholecystitis treated in our hospital from June 2020 to June 2022 were divided into observation group and control group by random number table, with 46 cases in each group. The control group underwent early LC and the observation group underwent PTCD continuous LC. SPSS 22.0 software was used to analyze the data. Perioperative indicators, visual analogue pain (VAS) score, liver function indicators and stress response indicators were expressed as (). Independent sample t test was used for comparison between groups, and paired sample t test was used for comparison before and after operation in the same group. The statistical data of postoperative complications were shown by [n (%)] and χ2 test was performed. P<0.05 was considered statistically significant.

LC operation time, anal exhaust time, indwelling drainage tube time and intraoperative blood loss in observation group were all lower than those in control group (P<0.05). VAS scores of patients in observation group 1 and 3 days after surgery, Alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), direct bilirubin (DBIL), white blood cell count (WBC), adrenal corticotropin (ACTH), cortisol (Cor) and the total incidence of complications at 7 days after operation were lower than those in control group (P<0.05).

PTCD followed by LC in the treatment of acute cholecystitis can reduce the stress response of the body, promote the recovery of liver function and reduce the occurrence of complications.