目的

探讨静脉注射吲哚菁绿导航手术在胃癌根治术中的安全性和有效性。

方法

纳入9例接受静脉吲哚菁绿给药后导航胃癌根治术患者入组，所有患者均实施标准的D2淋巴结清扫以及标本淋巴结分拣。吲哚菁绿注射时间分别为术前0.5h、术前4h和术前12h。对围手术期指标、肿瘤及淋巴结成像效果、肿瘤及淋巴结与周围组织信倍比、各站淋巴结分拣数目及总数目进行分析。

结果

纳入患者平均手术时间为（206.7±33.1）min，术中出血量为（161.1±48.6）ml，术后住院天数（10.1±1.8）d。9例患者均无严重并发症发生。三个时间点均能实现肿瘤及淋巴结的成像，0.5h肿瘤与正常胃黏膜组织产生最高信倍比（2.5±0.4），12h淋巴结与周围组织产生最高信倍比（1.9±0.6）。淋巴结总清扫数目为（74.0±29.2）枚。

结论

静脉吲哚菁绿导航胃癌根治术有效。

Objective

To investigate the safety and efficacy of intravenous indocyanine green navigation surgery in radical gastrectomy.

Methods

Nine patients receiving intravenous indocyanine green guided radical gastrectomy were enrolled.All patients underwent standard D2 lymph node dissection and lymph node sorting.Indocyanine green was injected at 0.5h, 4h and 12h before surgery, respectively.Perioperative indexes, imaging effects of tumor and lymph nodes, the ratio of tumor and lymph nodes to surrounding tissue,the number of lymph nodes sorted at each station and the total number were analyzed.Measurement data with normal distribution were represent as (Mean±SD).

Results

The mean operation time of the included patients was (206.7±33.1) min, the intraoperative blood loss was (161.1±48.6) ml, and the postoperative hospital stay was (10.1±1.8) d.None of the 9 patients had serious complications.The imaging of tumor and lymph nodes could be achieved at all three time points.The highest ratio of tumor to normal gastric mucosal tissue was (2.5±0.4) at 0.5h,and the highest ratio of lymph node to surrounding tissue was (1.9±0.6) at 12h.The total number of lymph nodes was (74.0±29.2).

Conclusions

Intravenous indocyanine green navigation radical gastrectomy is effective.