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中华普外科手术学杂志(电子版) ›› 2022, Vol. 16 ›› Issue (01) : 76 -78. doi: 10.3877/cma.j.issn.1674-3946.2022.01.022

论著

高龄复发性小肝癌再治疗方式的择取与安全性比较
赵刚1,(), 刘承利1, 何晓军1, 孔亚林1, 王林2, 郭坤2   
  1. 1. 100142 北京,中国人民解放军空军特色医学中心肝胆外科
    2. 230001 安徽合肥,安徽省立医院肝胆外科
  • 收稿日期:2020-12-08 出版日期:2022-02-26
  • 通信作者: 赵刚

Selection and safety comparison of retreatment methods for elderly patients with recurrent small hepatocellular carcinoma

Gang Zhao1,(), Chengli Liu1, Xiaojun He1, Yalin Kong1, Lin Wang2, Kun Guo2   

  1. 1. Department of hepatobiliary surgery, characteristic medical center of air force of PLA, Beijing 100142, China
    2. Department of hepatobiliary surgery, Anhui Provincial Hospital, Hefei Anhui Province 230001, China
  • Received:2020-12-08 Published:2022-02-26
  • Corresponding author: Gang Zhao
  • Supported by:
    Anhui Natural Science Foundation in 2020(2008085QH384)
引用本文:

赵刚, 刘承利, 何晓军, 孔亚林, 王林, 郭坤. 高龄复发性小肝癌再治疗方式的择取与安全性比较[J/OL]. 中华普外科手术学杂志(电子版), 2022, 16(01): 76-78.

Gang Zhao, Chengli Liu, Xiaojun He, Yalin Kong, Lin Wang, Kun Guo. Selection and safety comparison of retreatment methods for elderly patients with recurrent small hepatocellular carcinoma[J/OL]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2022, 16(01): 76-78.

目的

探讨高龄复发性小肝癌再治疗术式的择取,并对其安全性进行比较。

方法

回顾性分析2015年9月至2017年8月接受治疗的106例高龄复发性小肝癌患者资料,根据治疗方式不同分为再切除组(n=55例,再切除手术治疗)和射频组(n=51例,射频消融治疗)。用SPSS 23.0统计软件分析数据,住院时间、总生存时间等以(

xˉ
±s)表示,采用独立样本t检验;并发症、复发率等以率表示,采用χ2检验。累积生存率采用Log Rank检验。P<0.05为差异有统计学意义。

结果

再切除组住院时间比射频组长(P<0.05),两组患者总生存时间相比,差异无统计学意义(P>0.05)。再切除组患者术后1年、2年生存率及复发率与射频组相比,差异均无统计学意义(P>0.05)。射频组患者治疗后并发症总发生率为9.8%低于再切除组25.5%(P<0.05)。

结论

与二次手术切除相比,采用经皮射频消融治疗高龄复发性小肝癌患者在术后恢复、降低并发症方面具有明显优势,但两者近期疗效相似。

Objective

To explore the selection of the treatment methods for elderly recurrent small hepatocellular carcinoma(SHCC)and compare their safety.

Methods

The data of 106 elderly patients with recurrent small liver cancer who received treatment from September 2015 to August 2017 were retrospectively analyzed,and they were divided into resected group(n=55 cases,resected surgery)and radio frequency group(n=51 cases,radio frequency ablation)according to different treatment methods. SPSS 23.0 statistical software was used. Hospitalization time and total survival time were expressed as(

xˉ
±s),independent t test was used. The complication and recurrence rate were expressed by χ2 test. The cumulative survival rate was analyzed by log rank test. P<0.05 was considered statistically significant.

Results

The length of hospital stay in the re resected group was longer than that in the radiofrequency(RF)group(P<0.05);there was no significant difference in the total survival time between the two groups(P>0.05). There was no significant difference in the overall survival time between the two groups(P>0.05). There was no significant difference in 1-year and 2-year survival rate and recurrence rate between the resected group and the RF group(P>0.05). The total incidence of complications in the radiofrequency group was 9.8%,which was lower than 25.5% in resected group(P<0.05).

Conclusion

Compared with secondary resection,percutaneous radiofrequency ablation(PRFA)has significant advantages in postoperative recovery and reduction of complications in elderly patients with recurrent small hepatocellular carcinoma(HCC),but the short-term efficacy is similar.

表1 106例高龄复发性小肝癌不同治疗方式两组患者基线资料比较[(
xˉ
±s),例]
表2 106例高龄复发性小肝癌不同治疗方式两组患者住院时间及总生存时间(
xˉ
±s
表3 106例高龄复发性小肝癌不同治疗方式两组患者生存率及复发率比较[例(%)]
表4 106例复发性小肝癌不同治疗方式两组患者术后并发症比较[例(%)]
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