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中华普外科手术学杂志(电子版) ›› 2021, Vol. 15 ›› Issue (04) : 369 -373. doi: 10.3877/cma.j.issn.1674-3946.2021.04.004

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中国腹腔镜肝癌切除术20年发展、问题与对策
沈锋1,(), 邹奇飞1, 范明明1, 丛壮志1, 许志营1, 林建波1, 伍路1   
  1. 1. 海军军医大学东方肝胆外科医院,肝外四科一病区
  • 收稿日期:2020-08-01 出版日期:2021-08-17
  • 通信作者: 沈锋

Development, problems and Countermeasures of laparoscopic hepatectomy for liver cancer in recent 20 years in China

Feng Shen1,(), Qifei Zou1, Mingming Fan1, Zhuangzhi Cong1, Zhiying Xu1, Jianbo Lin1, Lu Wu1   

  1. 1. Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai 200433, China
  • Received:2020-08-01 Published:2021-08-17
  • Corresponding author: Feng Shen
  • Supported by:
    Application and transformation of precision medicine research project of the Second Military Medical University(2017JZ10)
引用本文:

沈锋, 邹奇飞, 范明明, 丛壮志, 许志营, 林建波, 伍路. 中国腹腔镜肝癌切除术20年发展、问题与对策[J/OL]. 中华普外科手术学杂志(电子版), 2021, 15(04): 369-373.

Feng Shen, Qifei Zou, Mingming Fan, Zhuangzhi Cong, Zhiying Xu, Jianbo Lin, Lu Wu. Development, problems and Countermeasures of laparoscopic hepatectomy for liver cancer in recent 20 years in China[J/OL]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2021, 15(04): 369-373.

我国腔镜肝切除始于上世纪90年代,历经起步摸索、交流发展、推广应用3个阶段。手术指征从起初的肝边缘的小肝癌拓展到尾状叶、VIII、VII段等各个肝段,肿瘤的大小限定逐渐拓宽。虽然腔镜肝癌切除的理论技术体系日臻成熟,安全性和有效性也渐被证实,但仍面临着较多的问题。主要在手术适应证、术中出血的控制、切缘的保证和疗效评估方面。随着腹腔镜设备的更新换代和技术的进步、经验的积累,目前腹腔镜的适应证已经逐步趋同开腹手术。低CVP法、经肝实质阻断入肝血流等技术的应用大大减少术中出血。腔镜用超声、荧光腹腔镜的出现,能最大限度得保证切缘。在长期疗效评估方面,仍需大型的多中心、前瞻性随机对照研究来验证。

The first laparoscopic hepatectomy (LH) in China was performed in 1990s. Thereafter, the technique of LH has evolved over three stages: the initial exploration, the exchange and development, and the promotion and application period. The indications of LH have been expanded from small liver tumors located at anterolateral segments to larger tumor of all segments (i.e., caudate lobe, segment VIII, and segment VII). The feasibility, safety and efficacy of LH have been demonstrated by increasing evidence. The techniques of LH has become sophisticated and standardized. And yet, the technique of LH remains challenging in the surgical indications, the control of intraoperative blood loss, the status of resected margins, and long-term outcome in patients with liver malignancies. With the update of laparoscopic instruments, the advancement of techniques, and improved operation skills, the indications for laparoscopic surgery are now very similar to open surgery. The application of new techniques including a low central venous pressure and transhepatic inflow blood ligation without portal dissection can minimize the intraoperative blood loss. Meanwhile, the availability of laparoscopic ultrasound and fluorescent imaging technique maximize the possibility of pursuing a tumor-free margin. Large-scale, multi-centre, prospective, randomized controlled studies are warranted to evaluate the long-term efficacy of laparoscopic hepatoma resection.

图1 腹腔镜下第二肝门肿瘤切除[(A) MRI显示肿瘤位置(箭头所指为肿瘤位置); (B)第二肝门处肿瘤切除术中图像]
图2 腹腔镜下左半肝切除[a:肿瘤位置;b:术中暴露左肝动脉;c:术中处理门静脉左支;d :确定肝表面预切线;e:闭合器离断左肝静脉;f:肝断面情况;g:完整切除左半肝及肿瘤;h:腹部切口[8]]
图3 第四代达芬奇机器人
图4 3D打印的肝脏模型[注:左图为标准3D打印和硅树脂浇铸制作的真人大小带病灶的肝脏模型,绿色为病灶,粉红色为门静脉,蓝色为肝静脉和下腔静脉;右图为模型指导下切除的病灶与模型对比[11]]
图6 低中心静脉压法[肝下下腔静脉阻断(A)与Pringle法(B)联用]
图7 ICG荧光成像系统对肝脏病灶的标识[正染:A:均质荧光(高分化肝细胞癌的典型特征);B:部分荧光(中分化肝细胞癌可见);C:肿瘤周围荧光(低分化肝细胞癌、结直肠癌肝转移、胆管癌中的荧光环)[16]]
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