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中华普外科手术学杂志(电子版) ›› 2024, Vol. 18 ›› Issue (01) : 96 -99. doi: 10.3877/cma.j.issn.1674-3946.2024.01.025

综述

肝再生细胞来源及调控机制的研究进展
叶晓琳, 刘云飞, 庞明泉, 王海久, 任利, 侯立朝, 于文昊, 王志鑫(), 樊海宁()   
  1. 810000 青海西宁,青海大学研究生院;810000 青海西宁,青海大学附属医院
    810000 青海西宁,青海大学附属医院普通外科学二科(肝胆胰)
    810000 青海西宁,青海大学附属医院普通外科学一科(肝胆胰)
  • 收稿日期:2023-07-13 出版日期:2024-02-26
  • 通信作者: 王志鑫, 樊海宁

Research progress on the sources and regulatory mechanisms of liver regenerative cells

Xiaolin Ye, Yunfei Liu, Mingquan Pang, Haijiu Wang, Li Ren, Lizhao Hou, Wenhao Yu, Zhixin Wang(), Haining Fan()   

  1. Graduate School of Qinghai University,Xining Qinghai Province 810000,China;Affiliated Hospital of Qinghai University,Xining Qinghai Province 810000, China
    Department 2 of General Surgery (Hepatobiliary and Pancreatic), Affiliated Hospital of Qinghai University, Xining Qinghai Province 810000, China
    Department 1 of General Surgery (Hepatobiliary and Pancreatic), Affiliated Hospital of Qinghai University, Xining Qinghai Province 810000,China
  • Received:2023-07-13 Published:2024-02-26
  • Corresponding author: Zhixin Wang, Haining Fan
  • Supported by:
    National clinical key specialty construction project in 2023(Green Health Office (2023) No. 125)
引用本文:

叶晓琳, 刘云飞, 庞明泉, 王海久, 任利, 侯立朝, 于文昊, 王志鑫, 樊海宁. 肝再生细胞来源及调控机制的研究进展[J/OL]. 中华普外科手术学杂志(电子版), 2024, 18(01): 96-99.

Xiaolin Ye, Yunfei Liu, Mingquan Pang, Haijiu Wang, Li Ren, Lizhao Hou, Wenhao Yu, Zhixin Wang, Haining Fan. Research progress on the sources and regulatory mechanisms of liver regenerative cells[J/OL]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(01): 96-99.

肝再生(LR)是肝细胞和分子之间的一组复杂机制,其中肝脏修复的启动、增殖和终止过程受到调节。肝脏在面对各类肝脏疾病以及治疗措施,其再生能力受到明显影响。另外,肝脏疾病是否能够缓解甚至治愈在很大程度上取决于肝细胞的再生能力,以实现肝功能的恢复。探索LR的发生机制及相关细胞来源,对于在不同病理模式下加速肝功能恢复,制定治疗策略具有重要意义。尽管LR已经得到了广泛的研究,但要充分理解仍然存在许多挑战。现就肝再生发生机制进行综述,以期对肝脏疾病的变化有一个新的认识,为肝脏疾病的治疗提供新的方向。

Liver regeneration (LR) is a complex set of mechanisms between liver cells and molecules in which the initiation, proliferation, and termination processes of liver repair are regulated. In the face of various liver diseases and treatment measures, the liver's regenerative capacity is significantly affected. In addition, whether liver diseases can be alleviated or even cured depends to a large extent on the regenerative ability of liver cells to achieve the recovery of liver function. Exploring the pathogenesis of LR and the related cell sources is of great significance for accelerating the recovery of liver function under different pathological modes and formulating therapeutic strategies. Although LR has been extensively studied, many challenges remain to fully understand it. This article reviews the mechanism of liver regeneration in order to have a new understanding of the changes of liver diseases and provide a new direction for the treatment of liver diseases.

[1]
Zhu CDong BSun L,et al. Cell Sources and Influencing Factors of Liver Regeneration: A Review[J]. Med Sci Monit, 2020, 26: e929129.
[2]
Preziosi MEMonga SP. Update on the Mechanisms of Liver Regeneration[J]. Semin Liver Dis, 2017, 37(2): 141–151.
[3]
Wan YGarner JWu N,et al. Role of stem cells during diabetic liver injury[J]. J Cell Mol Med, 2016, 20(2): 195–203.
[4]
Kopp J LGrompe MSander M. Stem cells versus plasticity in liver and pancreas regeneration[J]. Nat Cell Biol, 2016, 18(3): 238–245.
[5]
Wang BZhao LFish M,et al. Self-renewing diploid Axin2(+)cells fuel homeostatic renewal of the liver[J]. Nature, 2015, 524(7564): 180–185.
[6]
Dwyer BJMacmillan MTBrennan PN,et al. Cell therapy for advanced liver diseases: Repair or rebuild[J]. J Hepatol, 2021, 74(1): 185–199.
[7]
Tarlow BDPelz CNaugler WE,et al. Bipotential adult liver progenitors are derived from chronically injured mature hepatocytes[J]. Cell Stem Cell, 2014, 15(5): 605–618.
[8]
Best DHColeman WB. Liver regeneration by small hepatocyte-like progenitor cells after necrotic injury by carbon tetrachloride in retrorsine-exposed rats[J]. Exp Mol Pathol, 2010, 89(2): 92–98.
[9]
Ashmore-Harris CBlackford SJGrimsdell B,et al. Reporter gene-engineering of human induced pluripotent stem cells during differentiation renders in vivo traceable hepatocyte-like cells accessible[J]. Stem Cell Res, 2019, 41: 101599.
[10]
Raven ALu WYMan TY,et al. Corrigendum: Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration[J]. Nature, 2018, 555(7696): 402.
[11]
Deng XZhang XLi W,et al. Chronic Liver Injury Induces Conversion of Biliary Epithelial Cells into Hepatocytes[J]. Cell Stem Cell, 2018, 23(1): 114–122.
[12]
杨献光,朱琳,和春翠,等. 肝干细胞与肝损伤修复的研究进展[J]. 科技通报, 2017, 33(06): 90–95.
[13]
Magner NLJung YWu J,et al. Insulin and IGFs enhance hepatocyte differentiation from human embryonic stem cells via the PI3K/AKT pathway[J]. Stem Cells, 2013, 31(10): 2095–2103.
[14]
Luk STNg KYZhou L,et al. Deficiency in Embryonic Stem Cell Marker Reduced Expression 1 Activates Mitogen-Activated Protein Kinase Kinase 6-Dependent p38 Mitogen-Activated Protein Kinase Signaling to Drive Hepatocarcinogenesis[J]. Hepatology, 2020, 72(1): 183–197.
[15]
Tsolaki EAthanasiou EGounari E,et al. Hematopoietic stem cells and liver regeneration: differentially acting hematopoietic stem cell mobilization agents reverse induced chronic liver injury[J]. Blood Cells Mol Dis, 2014, 53(3): 124–132.
[16]
Watanabe YTsuchiya ASeino S,et al. Mesenchymal Stem Cells and Induced Bone Marrow-Derived Macrophages Synergistically Improve Liver Fibrosis in Mice[J]. Stem Cells Transl Med, 2019, 8(3): 271–284.
[17]
Lan LLiu RQin LY,et al. Transplantation of bone marrow-derived endothelial progenitor cells and hepatocyte stem cells from liver fibrosis rats ameliorates liver fibrosis[J]. World J Gastroenterol, 2018, 24(2): 237–247.
[18]
D'Avola DFernandez-Ruiz VCarmona-Torre F,et al. Phase 1-2 pilot clinical trial in patients with decompensated liver cirrhosis treated with bone marrow-derived endothelial progenitor cells[J]. Transl Res, 2017, 188: 80–91.
[19]
Unzu CPlanet EBrandenberg N,et al. Pharmacological Induction of a Progenitor State for the Efficient Expansion of Primary Human Hepatocytes[J]. Hepatology, 2019, 69(5): 2214–2231.
[20]
Michalopoulos GK. Advances in liver regeneration[J]. Expert Rev Gastroenterol Hepatol, 2014, 8(8): 897–907.
[21]
杨蕗璐,罗燕. 肝大部切除后肝脏再生的研究进展[J]. 世界华人消化杂志, 2016, 24(01): 67–74.
[22]
Jia C. Advances in the regulation of liver regeneration[J]. Expert Rev Gastroenterol Hepatol, 2011, 5(1): 105–121.
[23]
吴雄伟,郑永霞,蔺红梅,等. 肝再生机制的研究进展[J]. 四川生理科学杂志, 2016, 38(02): 100–103.
[24]
Fujiyoshi MOzaki M. Molecular mechanisms of liver regeneration and protection for treatment of liver dysfunction and diseases[J]. J Hepatobiliary Pancreat Sci, 2011, 18(1): 13–22.
[25]
Schaper FRose-John S. Interleukin-6: Biology,signaling and strategies of blockade[J]. Cytokine Growth Factor Rev, 2015, 26(5): 475–487.
[26]
Tao YWang MChen E,et al. Liver Regeneration: Analysis of the Main Relevant Signaling Molecules[J]. Mediators Inflamm, 2017, 2017: 4256352.
[27]
Michalopoulos GK. Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas[J]. Am J Pathol, 2010, 176(1): 2–13.
[28]
Zhao YYe WWang YD,et al. HGF/c-Met: A Key Promoter in Liver Regeneration[J]. Front Pharmacol, 2022, 13: 808855.
[29]
Mao SAGlorioso JMNyberg SL. Liver regeneration[J]. Transl Res, 2014, 163(4): 352–362.
[30]
Adas GKoc BAdas M,et al. Effects of mesenchymal stem cells and VEGF on liver regeneration following major resection[J]. Langenbecks Arch Surg, 2016, 401(5): 725–740.
[31]
Meyer JLejmi EFontana P,et al. A focus on the role of platelets in liver regeneration: Do platelet-endothelial cell interactions initiate the regenerative process[J]?J Hepatol, 2015, 63(5): 1263–1271.
[32]
Matsuo RNakano YOhkohchi N. Platelet administration via the portal vein promotes liver regeneration in rats after 70% hepatectomy[J]. Ann Surg, 2011, 253(4): 759–763.
[33]
Sakamoto TLiu ZMurase N,et al. Mitosis and apoptosis in the liver of interleukin-6-deficient mice after partial hepatectomy[J]. Hepatology, 1999, 29(2): 403–411.
[34]
Villevalois-Cam LRescan CGilot D,et al. The hepatocyte is a direct target for transforming-growth factor beta activation via the insulin-like growth factor II/mannose 6-phosphate receptor[J]. J Hepatol, 2003, 38(2): 156–163.
[35]
Romero-Gallo JSozmen EGChytil A,et al. Inactivation of TGF-beta signaling in hepatocytes results in an increased proliferative response after partial hepatectomy[J]. Oncogene, 2005, 24(18): 3028–3041.
[36]
Nygard IEMortensen KEHedegaard J,et al. The genetic regulation of the terminating phase of liver regeneration[J]. Comp Hepatol, 2012, 11(1): 3.
[37]
Yuan BDong RShi D,et al. Down-regulation of miR-23b may contribute to activation of the TGF-beta1/Smad3 signalling pathway during the termination stage of liver regeneration[J]. FEBS Lett, 2011, 585(6): 927–934.
[38]
Rogler CELevoci LAder T,et al. MicroRNA-23b cluster microRNAs regulate transforming growth factor-beta/bone morphogenetic protein signaling and liver stem cell differentiation by targeting Smads[J]. Hepatology, 2009, 50(2): 575–584.
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