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中华普外科手术学杂志(电子版)

中华普外科手术学杂志(电子版) ›› 2018, Vol. 12 ›› Issue (06) : 500 -502. doi: 10.3877/cma.j.issn.1674-3946.2018.06.016

所属专题： 文献；

论著

COX－2、CD31及CD105与胃癌分期及预后的关联性分析
刘晔1,†(), 李葵芳1, 顾慧1   
  1. 1. 214400　江苏江阴，南京中医药大学江阴附属医院病理科
  • 收稿日期:2018-05-22 出版日期:2018-12-26
  • 通信作者: 刘晔

Correlation analysis of the COX-2, CD31 and CD105 expression and the staging or prognosis of gastric cancer

Ye Liu1,†(), Kuifang Li1, Hui Gu1   

  1. 1. Department of Pathology, Jiangyin Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu, 214400, China
  • Received:2018-05-22 Published:2018-12-26
  • Corresponding author: Ye Liu
  • About author:
    Corresponding author: Liu Ye, Email:
  • Supported by:
    Project of Jiangsu Provincial Science and Technology Department(NO.20160 B122)
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刘晔, 李葵芳, 顾慧. COX－2、CD31及CD105与胃癌分期及预后的关联性分析[J]. 中华普外科手术学杂志(电子版), 2018, 12(06): 500-502.

Ye Liu, Kuifang Li, Hui Gu. Correlation analysis of the COX-2, CD31 and CD105 expression and the staging or prognosis of gastric cancer[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2018, 12(06): 500-502.

目的

探讨环氧合酶－2(COX－2)、血管标志物CD31及CD105与胃癌分期及预后的关联性分析。

方法

采用免疫组织化学方法检测2016年1月至2018年4月期间胃癌根治术48例患者病理标本中COX－2、CD31及CD105的表达水平，使用SPSS 19.0统计软件进行统计分析。CD31、CD105、COX－2表达阳性率采用χ2检验进行比较，相互关系检验采用Spearman相关分析。P<0.05差异有统计学意义。

结果

COX－2 、CD31及CD105蛋白表达与胃癌分期及预后显著相关(P<0.05)，而与患者的年龄、性别、肿瘤大小、肿瘤部位因素无关(P>0.05)。COX－2在胃癌组织中的阳性表达率为76.5%，而CD31及CD105在胃癌组织中的阳性表达率分别为68.8%和70.8%，COX－2与CD31(r＝0.532, P＝0.032)及CD105(r＝0.544, P＝0.029)的表达均存在相关性。

结论

COX－2、CD31及CD105蛋白在胃癌组织中高表达，且COX－2的表达与血管标志物CD31及CD105的表达存在相关性，可协同作为判断胃癌分期及预后的临床指标。

关键词: 胃肿瘤, 肿瘤分期, 环氧化酶2, 抗原，CD31, 预后
Objective

To investigate the correlation of the COX-2, CD31 and CD105 expression and the staging or prognosis of gastric cancer.

Methods

Immunohistochemistry was used to detect the expression levels of COX-2, CD31 and CD105 in 48 patients underwent radical gastrectomy from January 2016 to April 2018. Statistical analysis was performed by using SPSS 19.0 statistical software. The positive rates of CD31, CD105 and COX-2 expression were examined by using χ2 test, and the correlation test was performed by using Spearman correlation analysis. A P value < 0.05 was considered as statistically significant difference.

Results

The expression of COX-2, CD31 and CD105 was significantly correlated with the staging and prognosis of gastric cancer (P<0.05), but not with age, sex, tumor size and tumor location of these patients (P>0.05). The positive expression rate of COX-2 in gastric cancers was 76.5%, while the positive expression rates of CD31 and CD105 in gastric cancers were 68.8% and 70.8%, respectively. There was a correlation between COX-2 expression and vascular marker proteins CD31 (r=0.532, P=0.032) and CD105 (r=0.544, P=0.029).

Conclusion

COX-2, CD31 and CD105 are highly expressed in gastric cancer tissues. The expression of COX-2 is correlated with the expression of CD31 and CD105 in vascular markers which could be used as a clinical indicator for judging the staging and prognosis of gastric cancer.

Key words: Stomach Neoplasms, Neoplasm Staging, Cyclooxygenase 2, Antigens, CD31, Prognosis
表1 COX－2、CD31、CD105表达与48例胃癌患者临床病理资料的特征(例)
病理资料 例 COX－2 CD3 CD105
(＋) P (＋) P (＋) P
性别 ? ? ? ? ? ? ?
? 男 31 24 ? 21 ? 22 ?
? 女 17 11 0.06 12 0.05 12 0.05
年龄(岁) ? ? ? ? ? ? ?
? >60 26 20 ? 17 ? 19 ?
? ≤60 22 15 0.06 16 0.06 15 0.06
肿瘤大小 ? ? ? ? ? ? ?
? >5 cm 30 24 ? 22 ? 20 ?
? <5 cm 18 11 0.05 11 0.05 14 0.07
肿瘤部位 ? ? ? ? ? ? ?
? 胃体、贲门 31 23 ? 23 ? 22 ?
? 胃窦 17 12 0.05 10 0.09 12 0.06
临床分期 ? ? ? ? ? ? ?
? T1～T2 24 15 ? 15 ? 16 ?
? T3～T4 24 20 0.03 18 0.03 18 0.03
? N0 28 16 ? 19 ? 17 ?
? N1～N2 20 19 0.03 14 0.02 17 0.04
分化程度 ? ? ? ? ? ? ?
? 中－高分化 21 15 ? 16 ? 18 ?
? 低分化 27 20 0.02 17 0.03 16 0.04
预后 ? ? ? ? ? ? ?
? 较好 26 18 ? 18 ? 19 ?
? 较差 22 17 0.01 15 0.02 15 0.02
图1 COX－2在胃癌组织中的阳性表达( DAB，×200)
图2 CD31和CD105在胃癌组织中的阳性表达( DAB，×20)
表2 COX－2与血管标志物蛋白CD31及CD105表达相关性分析
? COX－2(＋) CD31(＋) CD105(＋) P1 P2
例数 35 33 34 ? ?
阳性率 76.5% 68.8% 70.8% 0.032 0.029
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