Abstract:

Objective

To investigate the clinical effect of microwave ablation （MWA） and trans-oral endoscopic thyroidectomy （TOET） in the treatment of stage T₁N₀M₀ papillary thyroid carcinoma （PTC）.

Methods

Totally 215 patients with PTC in the hospital from July 2019 to July 2023 were retrospectively selected，and were divided into two groups according to the different surgical methods.110 patients in the MWA group were treated with MWA，and 105 patients in the TOET group were given TOET.SPSS 25.0 statistical software was used to analyze the data.Count data was represented by［ cases （%）］ and tested using χ² test.Quantitative data was represented by （±s） and independent sample t test was performed.P＜0.05 was considered statistically significant

Results

All patients successfully completed the surgery.Compared with the TOET group，the MWA group had shorter surgical time，shorter hospital stay，less intraoperative blood loss，and lower VAS scores at 3，12 and 24 hours after surgery （P＜0.05）.Serum calcium and PTH were higher in the MWA group at 7 days after surgery compared with those in the TOET group （P＜0.05）.There was no significant difference in the incidence of postoperative complications between the TOET group and the MWA group （P＞0.05）.After 12 months of follow-up，no serious complications occurred in the two groups，and there were 3 cases of local recurrence in the MWA group and 0 cases in the TOET group.There was no significant difference in the local recurrence rate between the two groups （P＞0.05）.

Conclusion

MWA and TOET have their own advantages in the treatment of stage T₁N₀M₀ PTC.The former one is more advantageous in minimally invasive aspect，but it is not as good as TOET in the prognosis recurrence.In clinical practice，it is necessary to select personalized treatment regimen according to the actual situation of patients.

Key words: Thyroid Neoplasms, Carcinoma,Papillary, Microwave Ablation, Trans-Oral Endoscopic Thyroidectomy