Abstract:
Objective
To compare the effects of neoadjuvant chemotherapy combined with breastconserving surgery or modified radical mastectomy respectively on the serum tumor markers of triple-negative breast cancer.
Methods
The clinical data of 106 patients with triple-negative breast cancer from April 2021 to April 2023 were selected.According to different treatment methods，they were divided into the control group （n=50 cases，neoadjuvant chemotherapy + modified radical mastectomy） and the study group （n=56 cases，neoadjuvant chemotherapy + breast-conserving surgery）.The clinical efficacy，the levels of serum tumor markers before and after treatment，the occurrence of complications，the recurrence and metastasis rates one year after surgery of the two groups of patients were compared，and the breast aesthetic effects of the two groups of patients three months after surgery were evaluated.
Results
There was no significant difference in the total effective rate of treatment between the two groups of patients （P＞0.05）； compared with before treatment，the levels of carcinoembryonic antigen （CEA），carbohydrate antigen 125 （CA125），and carbohydrate antigen 153 （CA153） in both groups decreased after treatment，and there was no significant difference between the two groups （P＞0.05）；the incidence of complications in the study group was lower than that in the control group （P＜0.05）； there was no significant difference in the recurrence rate and metastasis rate one year after surgery between the two groups of patients （P＞0.05）； the breast aesthetic effect of the study group was better than that of the control group（P＜0.05）.
Conclusion
Neoadjuvant chemotherapy combined with breast-conserving surgery or modified radical mastectomy can achieve obvious effects in the treatment of triple-negative breast cancer.Among them，neoadjuvant chemotherapy combined with breast-conserving surgery can reduce complications and improve the breast aesthetic effect.
Key words:
Triple-negative Breast Cancer,
Breast-Conserving Surgery,
Modified Radical Resection,
Neoadjuvant Chemotherapy,
Tumor Markers
Na Yang, Gang Hu, Yue Pan. Influence of neoadjuvant chemotherapy after breast-conserving surgery and modified radical mastectomy on serum markers of triple-negative breast cancer[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2025, 19(03): 345-348.