To investigate the application of indocyanine green fluorescence imaging and negative carbon nano imaging in the identification of parathyroid glands during secondary surgery for recurrent thyroid cancer.

Fifty patients with recurrent thyroid cancer undergoing secondary surgery from January 2018 to December 2021 were selected as the study objects，and were divided into two groups with 25 patients in each group by paired grouping method. Indocyanine green fluorescence imaging technology was used in the observation group and negative carbon nanography technology was used in the control group. SPSS 20.0 software was used to complete all data analysis. Postoperative complications and other statistical data were represented by（examples）. Comparison between groups was performed by χ² test. Perioperative indicators，serum parathyroid hormone（PTH），blood calcium levels and other measurement data were represented by（

The accuracy of parathyroid identification in the observation group was significantly higher than that in the control group（χ²=4.635，P=0.031）. The operation cost in observation group was significantly lower than that in control group（P<0.05）. Compared with preoperative，serum PTH and blood calcium levels in 2 groups were significantly decreased 3 days and 1 month after surgery，and control group was significantly lower than observation group（P<0.05）. The total incidence of postoperative complications in observation group was significantly lower than that in control group（P<0.05），and the incidence of hypoparathyroidism was significantly lower than that in control group［1（4.0%）vs. 8（32.0%），P=0.027］.

Identification of parathyroid glands by indocyanine green fluorescence imaging technique during secondary surgery for recurrent thyroid cancer can improve the accuracy of parathyroid identification，reduce intraoperative injuries，and reduce the incidence of postoperative hypoparathyroid function，and has more economic advantages，which is worthy of clinical promotion.