To investigate and compare the efficacy and safety of unilateral axillary bilateral areola（UABA）approach and Da Vinci robotic surgery in the treatment of low-risk thyroid cancer with unilateral adenolotomy and unilateral central lymph node dissection.

The clinical data of 124 patients with thyroid cancer who underwent unilateral adenolotomy plus unilateral central lymph node dissection through the UABA approach from January 2019 to December 2019 were retrospectively analyzed. They were divided into two groups according to different operation methods：61 cases（robot group）and 63 cases（endoscopic group）. SPSS 25.0 software was used for statistical analysis. Perioperative indicators were expressed as（mean ± standard）deviation，and t test was used. Age，tumor size and number of central lymph nodes were represented by M（QR），and Mann-Whitney U test was used. Gender，tumor location，number of transplanted parathyroid glands，postoperative hypocalcemia and transient hypoparathyroidism were expressed by frequency and percentage using χ² test. P<0.05 was statistically significant.

The operative time and the number of parathyroid transplantation cases in the robot group were less than those in the endoscopic group（P<0.001）. The number of central lymph nodes in the robot group was significantly higher than that in the endoscopic group［8（6，12）vs. 6（3，8），P=0.021］. There was no significant difference in the number of metastatic lymph nodes and the incidence of postoperative complications between 2 groups（P > 0.05）.

Unilateral lobotomy via UABA approach and robotic surgery plus single central region dissection are both safe and effective for low-risk thyroid cancer，and robotic surgery can better preserve parathyroid glands in situ.