To investigate the efficacy of ICG fluorescence imaging in laparoscopic anatomic hepatectomy by laennec membrane approach.

74 patients with hepatocellular carcinoma admitted to our hospital from June 2019 to December 2022 were retrospectively selected as study subjects. All patients underwent laennec membrane approach laparoscopic anatomic hepatectomy, and were divided into ICG group (n=39) and non-ICG group (n=35) according to whether ICG was used in surgery. SPSS 24.0 was used to analyze the data. Perioperative indexes, liver function indexes and other measurement data of the two groups were expressed with (), and independent sample t test was used. The statistical data of postoperative complications were expressed by [n (%)] and χ² test was used. Kaplan-Meier method and Log-Rank test were used for survival analysis. P<0.05 was considered statistically significant.

The operation time, hilar occlusion time, drainage tube removal time and postoperative hospitalization time in ICG group were significantly shorter than those in non-ICG group, the incision margin distance was longer than that in non-ICG group, and the intraoperative blood loss was less than that in non-ICG group (P<0.05). The levels of ALT, AST and ALB in both groups were significantly higher than those before surgery, and the non-ICG group was significantly higher than the ICG group (P<0.05).There was no significant difference in the total incidence of postoperative complications between the two groups (10.4% vs 14.3%). Cumulative DFS and OS were compared between the two groups (74.4% vs. 68.6%, 79.5% vs. 71.4%), and there was no statistical significance (P>0.05).

The application of ICG fluorescence imaging technology in laennec membrane approach laparoscopic anatomic hepatectomy can accurately locate the tumor location and track and determine the hepatectomy interface in real time within the hepatic parenchyma, which is more conducive to guiding the accurate surgical resection, protecting the normal hepatic parenchyma to the maximum extent, shortening the intraoperative portal blocking time and operation time, reducing intraoperative blood loss, and promoting the postoperative liver function recovery of patients.