Abstract:
Objective To investigate the risk factors for central lymph node metastasis (CLNM) and extra-glandular invasion (ETE) in minimal papillary thyroid carcinoma (PTMC).
Methods Retrospective analysis was performed on the data of 157 patients with PTMC who received thyroid surgery for the first time from May 2017 to December 2019.All patients underwent central lymph node dissection during surgery, and the occurrence of ETE was determined by postoperative pathology. SPSS 25.0 statistical software was used for analysis. Univariate and logstic multivariate regression analysis was performed on the clinicopathological factors related to CLNM and ETE, and the difference was statistically significant at P<0.05.
Results CLNM occurred in 45 (28.7%) of 157 PTMC patients, and ETE occurred in 23 (14.6%) patients. Logstic multivariate regression analysis showed that age < 55 years old, male, BRAF V600E gene mutation positive, tumor diameter >5 mm, bilateral multifocal glandular lobes and capsule invasion were independent risk factors for CLNM (P<0.05). Tumor diameter was > 5 mm and bilateral glandular lobes were independent risk factors for ETE (P<0.05).
Conclusion Age < 55 years old, male, positive BRAFV600E gene mutation positive, tumor diameter > 5 mm, bilateral glandular leaves and capsule invasion are independent risk factors for CLNM, tumor diameter > 5 mm, bilateral multiple foci of glandular leaves are independent risk factors for ETE.
Key words:
Thyroid neoplasms,
Carcinoma, papillary,
Central lymph node metastasis,
Extraglandular invasion
Yuanqing Wu, Jie Lin, Jiabao Luo, Kun Qiu, Ping Hong. Risk factors for lymph node metastasis and extra-glandular invasion in thyroid micropapillary carcinoma[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2021, 15(03): 319-322.