To investigate the effectiveness of controlled low central venous pressure (CLCVP) in complex hepatic lobectomy.

A prospective study was conducted in 120 patients with primary hepatocellular carcinoma who underwent complex lobectomy from September 2015 to September 2017. The patients were divided into conventional group and CLCVP group according to random digitization method. Conventional control of central venous pressure (6~12 cmH₂O) was given in the conventional group, while controlled low central venous pressure (≤5 cmH₂O) was given in the CLCVP group. SPSS19.0 statistical software was used for data processing. The intraoperative and postoperative indicators, liver and kidney function indicators, preoperative, intraoperative, 1h and 24h hemoglobin indicators were expressed by , and compared with independent t test. The counting data were compared by χ² test, P<0.05 showed significant difference.

The patients’ intraoperative and postoperative status of CLCVP group was significantly better than that of conventional group. Compared with pre-operation, the hemoglobin content in both groups decreased significantly during operation and after operation, and the hemoglobin content in conventional group was lower than that in CLCVP group at the same time (P<0.05). The levels of ALT and AST in the two groups increased significantly on the 1st, 4th and 7th day, which in the CLCVP group were significantly lower than those in the conventional group on the 1st and 4th day after operation (P<0.05). There was no significant difference in TBIL, BUN and Cr levels between the two groups after operation (P>0.05).

The application of CLCVP in complex hepatic lobectomy can effectively reduce the amount of bleeding during operation, and has less effect on liver function.