To investigate the clinical effect of radiofrequency ablation (RFA) combined with laparoscopic anatomic hemihepatectomy (LAH) in the treatment of primary liver cancer (PLC) with portal vein cancer thrombus (PVTT).

The clinical data of 125 PLC patients with PVTT treated from June 2018 to June 2019 were retrospectively analyzed, and they were divided into observation group (n=73, RFA combined with LAH) and control group (n=52, RFA treatment) according to the surgical method. The short-term clinical efficacy and perioperative indexes (operation time, intraoperative blood loss, length of hospital stay) were compared between the two groups. Pain level at 12h, 24h, 48h, 72h after surgery [visual analogue scale (VAS)]; Liver function indexes were recorded before and 7 days after operation. Complications and recurrence were compared between the two groups. Statistical analysis was processed by SPSS 24.0 software, and measurement data were presented in the form of (), and t test was adopted. Count data were represented by [cases (%)], clinically relevant differences were evaluated by Chi-square test, and grade data were represented by [cases (%)], and Z test was performed. P<0.05 was considered statistically significant.

There was no statistical significance in the short-term clinical effect between the two groups (P>0.05). The intraoperative blood loss and hospital stay in the observation group were significantly lower than those in the control group (P<0.05), and there was no statistical significance in the operation time between the two groups (P>0.05). VAS scores in observation group were significantly lower than control group at 12h, 24h, 48h and 72h after operation (P<0.05). On the 7th day after operation, the level of liver function indexes in two groups was significantly lower than before operation, and the observation group was significantly lower than the control group (P<0.05). There was no statistical significance in the incidence of complications between the two groups (P>0.05), and the recurrence rate of observation group was lower than that of control group (P<0.05).

LAH intraoperative adjuvant use of RFA in the treatment of primary liver cancer with portal vein cancer embolus has a good effect.