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中华普外科手术学杂志(电子版) ›› 2023, Vol. 17 ›› Issue (06) : 701 -704. doi: 10.3877/cma.j.issn.1674-3946.2023.06.030

综述

洗脱液甲状腺球蛋白在甲状腺乳头状癌转移淋巴结中的应用
徐成, 王璐璐, 王少华()   
  1. 210004 南京,南京医科大学附属妇产医院(南京市妇幼保健院)普通外科
  • 收稿日期:2023-07-29 出版日期:2023-12-26
  • 通信作者: 王少华

Application of eluent thyroglobulin in metastatic lymph nodes of thyroid papillary carcinoma

Cheng Xu, Lulu Wang, Shaohua Wang()   

  1. Department of General Surgery, Women’s Hospital of Nanjing Medical University, Nanjing Maternity Hospital and Child Health Care Hospital, Nanjing 210004, China
  • Received:2023-07-29 Published:2023-12-26
  • Corresponding author: Shaohua Wang
  • About author:

    Xu Cheng and Wang Lulu are co-first authors

引用本文:

徐成, 王璐璐, 王少华. 洗脱液甲状腺球蛋白在甲状腺乳头状癌转移淋巴结中的应用[J]. 中华普外科手术学杂志(电子版), 2023, 17(06): 701-704.

Cheng Xu, Lulu Wang, Shaohua Wang. Application of eluent thyroglobulin in metastatic lymph nodes of thyroid papillary carcinoma[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2023, 17(06): 701-704.

在甲状腺乳头状癌(PTC)颈部淋巴结(CLN)转移的诊断中,细针穿刺洗脱液甲状腺球蛋白(FNA-Tg)的临床应用获得广泛关注。对于体积较小或囊性变的颈部淋巴结,FNA-Tg诊断颈部转移淋巴结的价值高于超声(US)和细针穿刺细胞学(FNAC)检查。另外,FNA-Tg联合FNAC诊断颈部淋巴结转移的敏感性和特异性接近100%。然而,由于研究中样本差异、检测方法以及试剂盒多样等原因,转移性颈部淋巴结的FNA-Tg的诊断阈值尚未标准化,目前已报道的诊断阈值多在0.2~77 ng/ml之间。FNA-Tg检测的准确性主要受血清抗甲状腺球蛋白抗体水平、血清甲状腺球蛋白水平、甲状腺是否切除以及颈部淋巴结特征等因素影响。本文综述了近年来FNA-Tg在PTC颈淋巴结转移诊断中的应用及研究,为临床PTC颈部淋巴结转移的诊断提供可靠依据。

In the diagnosis of cervical lymph node (CLN) metastasis of papillary thyroid carcinoma (PTC), fine needle aspiration eluent thyroglobulin (FNA-Tg) has received extensive attention. For small or cystic cervical lymph nodes, FNA-Tg is more valuable than ultrasound (US) and fine needle aspiration cytology (FNAC) in the diagnosis of cervical metastatic lymph nodes. In addition, the sensitivity and specificity of FNA-Tg combined with FNAC in the diagnosis of cervical lymph node metastasis were close to 100%. However, due to sample differences, various detection methods and kits in studies, the diagnostic threshold of FNA-Tg in metastatic cervical lymph nodes has not been standardized, and most of the reported diagnostic thresholds range from 0.2 to 77 ng/ml. The accuracy of FNA-Tg detection was mainly affected by the level of serum anti-thyroglobulin antibody, serum thyroglobulin level, whether the thyroid was resected or not, and the characteristics of cervical lymph nodes. This article reviews the application and research of FNA-Tg in the diagnosis of cervical lymph node metastasis of PTC in recent years, which provides a reliable basis for the diagnosis of cervical lymph node metastasis of PTC.

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