Effect of obesity on surgical treatment of gastric cancer patients

doi:10.3877/cma.j.issn.1674-3946.2023.06.018

Abstract

Abstract:

Objective

To study the effect of obesity on surgical treatment of gastric cancer patients.

Methods

Clinical data of 132 patients undergoing laparoscopic radical gastrectomy from May 2018 to June 2023 were retrospectively analyzed. According to body mass index（BMI）≥25.0 kg/m²，they were divided into obese group （n=45 cases）and non-obese group（n=87 cases）. SPSS 20.0 software was used for data processing. Measurement data such as perioperative indicators were expressed by（

x ¯

±s），and independent sample t test was performed. The statistical data of postoperative complications were compared by χ² test. P < 0.05 indicated that the difference was statistically significant.

Results

Compared with the non-obese group，the operation duration，postoperative hospitalization days and anal exhaust time in the obese group were significantly longer，the amount of intraoperative blood loss was significantly more，the number of lymph nodes dissection was significantly less，and the incidence of postoperative complications was significantly higher than that in the non-obese group（23.7% vs. 7.8%），with statistical significance （P < 0.05）. The expression levels of interleukin-6（IL-6），tumor necrosis factor α（TNF-α）and C-reactive protein（CRP）in obese group were significantly higher than those in non-obese group before and after operation，with statistical significance （P < 0.05）.

Conclusion

Obesity may be one of the influencing factors leading to a decrease in surgical efficacy in gastric cancer patients，and it is worthy of increasing clinical attention.

Key words: Stomach Neoplasms, Obesity, Postoperative Complications, Inflammatory Factors

Damin Chen, Xiaogang Cao, Nengqi Cao. Effect of obesity on surgical treatment of gastric cancer patients[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2023, 17(06): 651-653.

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References 19

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组别	例	性别 (男/女)	年龄 (岁)	平均BMI (kg/m²)	平均肿瘤大小 (cm)
肥胖组	45	27/18	54.4±7.3	26.1±0.9	3.1±0.7
非肥胖组	87	49/38	53.9±7.2	23.4±0.8	3.3±0.7
t/χ²值		0.164	0.376	17.606	1.556
P值		0.685	0.707	0.000	0.122
组别	例	肿瘤位置 A/B/C	淋巴结转移N₀/N₁/N₂/N₃	浸润深度 T₁/T₂/T₃	手术方式 D/E
肥胖组	45	17/16/12	15/14/14/2	14/20/11	27/18
非肥胖组	87	32/33/22	37/20/21/9	25/32/30	42/45
χ²值		0.012	1.050	0.080	1.634
P值		0.864	0.406	0.237	0.201

组别	例	性别 (男/女)	年龄 (岁)	平均BMI (kg/m²)	平均肿瘤大小 (cm)
肥胖组	45	27/18	54.4±7.3	26.1±0.9	3.1±0.7
非肥胖组	87	49/38	53.9±7.2	23.4±0.8	3.3±0.7
t/χ²值		0.164	0.376	17.606	1.556
P值		0.685	0.707	0.000	0.122
组别	例	肿瘤位置 A/B/C	淋巴结转移N₀/N₁/N₂/N₃	浸润深度 T₁/T₂/T₃	手术方式 D/E
肥胖组	45	17/16/12	15/14/14/2	14/20/11	27/18
非肥胖组	87	32/33/22	37/20/21/9	25/32/30	42/45
χ²值		0.012	1.050	0.080	1.634
P值		0.864	0.406	0.237	0.201

组别	例	手术时间(min)	术中出血量(ml)		淋巴结清扫数目(枚)
肥胖组	45	205.1±18.2	104.8±25.5		18.9±4.4
非肥胖组	87	184.5±19.6	84.1±22.3		25.1±5.8
t/χ²值		5.862	4.811		6.291
P值		0.000	0.000		0.000
组别	例	术后住院天数(d)		肛门排气时间(d)
肥胖组	45	11.6±2.1		3.3±1.3
非肥胖组	87	9.6±1.2		1.9±0.8
t/χ²值		6.965		7.642
P值		0.000		0.000

组别	例	手术时间(min)	术中出血量(ml)		淋巴结清扫数目(枚)
肥胖组	45	205.1±18.2	104.8±25.5		18.9±4.4
非肥胖组	87	184.5±19.6	84.1±22.3		25.1±5.8
t/χ²值		5.862	4.811		6.291
P值		0.000	0.000		0.000
组别	例	术后住院天数(d)		肛门排气时间(d)
肥胖组	45	11.6±2.1		3.3±1.3
非肥胖组	87	9.6±1.2		1.9±0.8
t/χ²值		6.965		7.642
P值		0.000		0.000

组别	例	幽门梗阻	切口感染	切口出血	残胃无力	吻合口漏	总发生(%)
肥胖组	45	1	3	2	3	1	10(22.2)
非肥胖组	87	1	1	2	1	1	6(6.9)
χ²值		-	-	-	-	-	6.539
P值		-	-	-	-	-	0.011

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