The clinical effects of three hepatic blood flow occlusion techniques in laparoscopic hepatectomy were compared to analyze the effects of the three techniques on oxidative stress injury and liver and kidney function in patients with liver cancer.

The clinical data of 143 patients with hepatocellular carcinoma undergoing laparoscopic hepatectomy from January 2017 to January 2021 were retrospectively analyzed. According to different blood occlusion methods，the patients were divided into group A（hepatic blood flow occlusion by Pringle method，n=59 cases）and group B（hepatic blood flow occlusion by modified Pringle method，n=33 cases）and C group（improved Pringle method + inferior vena cava method，n=51 cases）. SPSS 22.0 statistical software was used for data analysis. Perioperative indicators，oxidative stress indicators and liver and kidney function indicators were expressed as（

The amount of intraoperative blood loss and blood transfusion in group C were significantly less than those in groups A and B（P<0.05）. There was no significant difference in the incidence of postoperative complications among the three groups（P>0.05）. The level of superoxide dismutase in group C was higher than that in groups A and B at 3 and 7 days after operation（P<0.05）. The level of malondialdehyde in group C was significantly lower than that in group A and B at 1 and 3 days after operation（P<0.05）. The level of glutathione peroxidase in group C was higher than that in groups A and B at 1 and 3 days after operation（P<0.05）. The levels of alanine aminotransferase，aspartate aminotransferase and total bilirubin in group C were significantly lower than those in group A at 1，3 and 7 days after operation（P<0.05）. There were no significant differences in postoperative creatinine and urea nitrogen levels among the three groups（P>0.05）.

Modified pringle method combined with inferior vena cava blocking method can reduce intraoperative blood loss in patients with liver cancer，and has less damage to oxidative stress and liver function.