To analyze the relationship between symptomatic venous thromboembolism（VTE）and clinical features during perioperative period of hepatectomy，and to establish a risk assessment model to predict the high risk population of VTE.

The clinical data of 206 patients who underwent hepatectomy from January 2017 to June 2020 were collected.According to the diagnostic criteria of perioperative symptomatic VTE，the patients were divided into VTE group（n=45 cases）and non-VTE group（n=161 cases）. SPSS 20.0 software was used for univariate and multivariate Logistic regression analysis of the relationship between VTE and clinical features，and P<0.05 was considered as statistically significant. The risk assessment model for symptomatic VTE in hepatectomy patients was constructed. The evaluation ability of the model was evaluated by describing the receiver operating characteristic curve（ROC）and calculating the area under the curve（AUC）. The evaluation model was verified by the actual postoperative outcome as the gold standard.

There were statistically significant differences between the two groups in BMI，VTE history，liver malignancy，operation time，postoperative pulmonary infection，use of intermittent pneumatic pressurization device（IPC），and D-dimer concentration（P<0.05）. Multivariate Logistic regression analysis showed that the history of VTE，hepatic malignancy，operation time≥3 h，postoperative pulmonary infection and D-dimer≥0.2 mg/L were independent risk factors for perioperative symptomatic VTE in patients undergoing hepatectomy，and postoperative IPC use was a protective factor for perioperative symptomatic VTE in patients undergoing hepatectomy. The AUC value of the VTE risk assessment model was 0.913（95%CI：0.869~0.974，P=0.004）.When the optimal critical value of Y is 2.85，it had evaluation value for the risk of VTE，with a sensitivity of 86.7%，specificity of 89.4% and Yoden index of 0.761. The diagnostic accuracy，sensitivity and specificity of the evaluation model were 92.7%（191/206），80.0%（36/45）and 96.3%（155/161），respectively，based on the actual occurrence of postoperative VTE.

History of VTE，hepatic malignancy，operation time ≥3 h，postoperative pulmonary infection and D-dimer ≥0.2 mg/L were independent risk factors for perioperative symptomatic VTE.The risk assessment model of perioperative symptomatic VTE in patients with hepatectomy established in this study has high predictive value for the occurrence of VTE and has good applicability.