Application of eluent thyroglobulin in metastatic lymph nodes of thyroid papillary carcinoma

doi:10.3877/cma.j.issn.1674-3946.2023.06.030

Abstract

Abstract:

In the diagnosis of cervical lymph node (CLN) metastasis of papillary thyroid carcinoma (PTC), fine needle aspiration eluent thyroglobulin (FNA-Tg) has received extensive attention. For small or cystic cervical lymph nodes, FNA-Tg is more valuable than ultrasound (US) and fine needle aspiration cytology (FNAC) in the diagnosis of cervical metastatic lymph nodes. In addition, the sensitivity and specificity of FNA-Tg combined with FNAC in the diagnosis of cervical lymph node metastasis were close to 100%. However, due to sample differences, various detection methods and kits in studies, the diagnostic threshold of FNA-Tg in metastatic cervical lymph nodes has not been standardized, and most of the reported diagnostic thresholds range from 0.2 to 77 ng/ml. The accuracy of FNA-Tg detection was mainly affected by the level of serum anti-thyroglobulin antibody, serum thyroglobulin level, whether the thyroid was resected or not, and the characteristics of cervical lymph nodes. This article reviews the application and research of FNA-Tg in the diagnosis of cervical lymph node metastasis of PTC in recent years, which provides a reliable basis for the diagnosis of cervical lymph node metastasis of PTC.

Key words: Thyroid Neoplasms, Carcinoma, Papillary, Fine Needle Aspiration-Thyroglobulin, Lymph Node Metastasis

Cheng Xu, Lulu Wang, Shaohua Wang. Application of eluent thyroglobulin in metastatic lymph nodes of thyroid papillary carcinoma[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2023, 17(06): 701-704.

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