Abstract:
Objective To analyze the relationship between dietary inhibitory factor 1（Nesfatin-1）and liver metastasis after laparoscopic radical resection of colorectal cancer.
Methods A prospective cohort study of 83 patients who underwent laparoscopic radical resection for colorectal cancer between January 2019 and December 2021 was included. Serum Nesfatin-1 levels were measured in all patients upon admission，and patients were divided into a high level group（n=37）and a low level group（n=46）according to a median value of 119.8pg/ml. All patients were followed up for 1 year from the date of discharge by outpatient revisit. The incidence of liver metastasis in the two groups during the follow-up period was analyzed using SPSS 25.0 data. The measurement data were expressed as（
±
s），and inter-group independent sample
t test was performed. The counting data were expressed by frequency or rate and
χ2 test was used.
Rank sum test was used for rank data，and point two-column correlation was used for correlation analysis. The receiver operating characteristic curve（
ROC）was drawn using multi-factor Logistics regression analysis，and the area under the curve（
AUC）was used to test the predictive value of Nesfatin-1 level in liver metastasis in patients undergoing radical resection of colorectal cancer.
P<0.05 was considered statistically significant.
Results The proportion of nerve involvement in high level group was higher than that in low level group（P < 0.05）. The level of Nesfatin-1（124.3±12.9）pg/ml and the incidence of liver metastases in the high level group were higher than those in the low level group（116.2±13.0）pg/ml and the incidence of liver metastases（24.3%），the difference was statistically significant（P < 0.05）. Nesfatin-1 level was positively correlated with liver metastasis in patients undergoing laparoscopic radical resection for colorectal cancer（r=0.331，P < 0.05）. After adjusting for nerve involvement and confounding factors，Nesfatin-1 was still an independent risk factor for liver metastasis in patients undergoing laparoscopic radical resection for colorectal cancer（OR=1.119，95%CI：1.036-1.209， P=0.004）. Receiver operating characteristic curve（ROC）showed that Nesfatin-1 was a good predictor of liver metastasis after laparoscopic radical resection of colorectal cancer.
Conclusion Nesfatin-1 is independently associated with the occurrence of liver metastasis after laparoscopic radical resection of colorectal cancer，and it has a good predictive effect on liver metastasis after laparoscopic radical resection of colorectal cancer，and may be used as a predictor of liver metastasis in patients with laparoscopic radical resection of colorectal cancer.
Key words:
Colorectal Neoplasms,
Proctocolectomy,
Laparoscopes,
Ingestion Inhibition Factor-1,
Liver Metastasis
Jian Chang, Feng Qiu, Yuqi Mao. Analysis of the relationship between ingestion inhibition factor-1 and liver metastasis after laparoscopic radical resection of colorectal cancer[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2023, 17(05): 502-505.