Abstract:
Objective To investigate the difference of recent follow-up results between laparoscopic D2 radical surgery and conventional open radical surgery in advanced gastric cancer patients treated with Ticeo combined with oxaliplatin (SOX) neoadjuvant chemotherapy.
Methods Clinical data of 91 patients who underwent surgery after SOX neoadjuvant chemotherapy from January 2020 to September 2022 were retrospectively analyzed. 46 patients underwent laparoscopic D2 radical resection for gastric cancer (endoscopy group) and 45 patients underwent laparotomy (laparotomy group). SPSS 27.0 software was used to analyze the data. Perioperative indicators, immune function and other measurement data were described by (
), and independent sample t test was used. The statistical data of postoperative complications were measured by χ2 test. Kaplan-Meier curve was used to analyze the survival of the patients. P<0.05 was considered statistically significant.
Results The time of gastrointestinal function recovery and hospital stay in laparoscopy group were shorter than those in laparotomy group, the amount of intraoperative blood loss was less than that in laparotomy group, and the operative time was longer than that in laparotomy group (P<0.05). There was no significant difference in the number of lymph nodes between the two groups (P>0.05). The levels of 3dCD4+ and CD4+/CD8+ in endoscopic group were higher than those in laparotomy group, and CD8+ was lower than those in laparotomy group (P<0.05). The levels of interleukin-6 (IL-6), procalcitonin and C-reactive protein (CRP) in 1d and 3d endoscopic group were lower than those in open group (P<0.05). There was no significant difference in survival time between the two groups (P>0.05).
Conclusion Laparoscopic D2 radical surgery for gastric cancer after SOX neoadjuvant chemotherapy can achieve short-term efficacy comparable to that of open radical surgery, but laparoscopic D2 radical surgery for gastric cancer has the advantages of less intraoperative blood loss, length of hospital stay, short recovery time of gastrointestinal function, fewer postoperative complications, and less stress reaction.
Key words:
Stomach Neoplasms,
Laparoscopes,
Tigio,
Oxaliplatin,
Neoadjuvant Chemotherapy,
Postoperative Complications
Jie Xu, Yajun Li, Yiwen Feng. Comparison of recent follow-up between laparoscopic D2 radical surgery and conventional radical surgery for advanced gastric cancer after SOX neoadjuvant chemotherapy[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(06): 647-650.