To investigate the application effect of indocyanine green fluorescence fusion imaging（FIGFI）technique in laparoscopic total gastrectomy（LTG）+Roux-EN-Y anastomosis. Methods From January 2018 to December 2020，86 gastric cancer patients who underwent LTG+Roux-EN-Y anastomosis were selected as the research objects. The patients were divided into conventional group and FIGFI group by random number table method，with 43 cases in each group. Routine group：routine LTG+Roux-en-Y anastomosis；FIGFI group：LTG+Roux-en-Y anastomosis was performed under FIGFI technique. The data were processed by SPSS 22.0 software. The measurement data of perioperative related indicators were represented by（

There were no significant differences in operation time，intraoperative blood loss，postoperative exhaust time and postoperative hospital stay between the two groups（P>0.05），while the number of lymph nodes dissected in the FIGFI group was significantly higher than that in the conventional group（P<0.05）. There was no significant difference in the incidence of postoperative complications between the two groups（9.3% vs. 18.6%，P>0.05）. The cumulative overall survival rate（88.4% vs. 74.4%）and disease-free survival rate（86.0% vs. 69.8%）in the FIGFI group were significantly higher than those in the conventional group（Log-Rank χ²=3.918，4.231，P=0.048，0.045）.

FIGFI technique is safe and effective in LTG+ Roux-EN-Y anastomosis. It can not only improve the thoroughness and safety of lymph node dissection，reduce the incidence of postoperative complications，especially has a positive effect on reducing the occurrence of postoperative anastomotic leakage，and is conducive to the prognosis of patients，which is worthy of clinical application.