To investigate the clinical efficacy of laparoscopic anatomical and non-anatomical hepatectomy for liver cancer.

According to the prospective randomized controlled trial, 106 patients with hepatocellular carcinoma admitted to our hospital from January 2015 to February 2018 were divided into the anatomical group (laparoscopic anatomical hepatectomy) and the non-anatomical group (laparoscopic non-anatomical hepatectomy) according to the random number table method, 53 cases in each group. Statistical analysis were performed by using SPSS20.0 software. Measurement data, such as Perioperative indicators and liver function indicators were expressed as (±s), and were examined by using independent t test. The incidence of complications, recurrence and metastasis rate and 1-year survival rate were analyzed by using 2 test. A P value <0.05 was considered as statistically significant difference.

The operation time in the anatomical group was much longer than that in the non-anatomical group, however the amount of bleeding and blood transfusion during the operation was significantly less and the hospital stay was significantly shorter than that in the non-anatomical group (P<0.05). The serum ALT and TBIL values in non-anatomical group were significantly higher than those in anatomical group on the POD 1, 3 and 7 (P<0.05), and the serum AST values in anatomical group were significantly lower than those in non-anatomical group on the POD 1 and 3 respectively (P<0.05). The incidence of postoperative complications was 7.5% in the anatomical group and 22.6% in the non-anatomical group. The overall incidence of postoperative complications in the anatomical group was lower than that in the non-anatomical group (P<0.05). The 1-year overall survival rates in the anatomical group and the non-anatomical group were 94.3% and 88.6% respectively, with no significant difference between the two groups (P>0.05); The 1-year tumor-free survival rates were 90.6% and 75.5% (P=0.038), respectively, wtih significant difference between the two groups (P<0.05).

Compared with laparoscopic non-anatomical hepatectomy, laparoscopic anatomical hepatectomy has better clinical effect and could effectively improve one-year disease-free survival rate, which is worthy of further clinical application.