To investigate the feasibility and safety of laparoscopic single-anastomosis duodenal-jejunal bypass with sleeve gastrectomy (SADJB-SG) in the treatment of obese patients with non-alcoholic fatty liver disease (NAFLD).

A retrospective analysis were performed in 97 obese patients with NAFLD from August 2017 to October 2019. According to the surgical options, 97 patients were divided into SADJB-SG group (n=45) and LSG group (laparoscopic sleeve gastrectomy, (n=52). Statistical analysis were performed by using SPSS 24.0 software. The measurement data such as surgery-related indicators, LSM, and CAP were expressed as (±s), and were examined by using independent t-tests. The incidence of complication were analyzed by using χ² test. A P value of <0.05 was considered as statistically significant difference.

The operation time and blood loss in SADJB-SG group were much longer than those in LSG group respectively (P<0.05); The hospital stay in the SADJB-SG group was slightly longer than that in the LSG group, and the total incidence of postoperative complications was slightly higher than that in the LSG group (20.0% vs. 13.5%), without significant difference (P>0.05). 3 months after surgery, the body weight and BMI in both groups were significantly lower than those before the operation respectively (P<0.05), without significant difference (P>0.05). LSM and CAP in the SADJB-SG group were higher than those in the LSG group on 3 months postoperation (P<0.05).

Clinical outcome of SADJB-SG is statisfactory in treating obese patients with NAFLD, including effectively reduce weight and improve liver function without increasing the incidence of complications.