To investigate the clinical outcome and complications of radical resection of hilar cholangiocarcinoma based on enhanced recovery after surgery principles.

From March 2017 to March 2019, clinical data of 45 patients underwent radical resection of portal cholangiocarcinoma were analyzed retrospectively. 21 patients were divided into the enhanced recovery after surgery group (EARS group) and 24 patients were divided into the conventional group. Statistical analysis were performed by using SPSS24.0 software. Measurement data such as perioperative indicators, VAS pain scores, stress response indicators were represented as (±s) and were examined by using independent t test. Postoperative complications were analyzed by using χ² test. A P value of <0.05 was considered as statistical significant difference.

The intraoperative blood loss and postoperative recovery indicators in the EARS group were better than those in the conventional group, and the operation time was much longer than that in the conventional group (P<0.05). There was no significant difference, in terms of intraoperative lymph node dissection time and total incidence of postoperative complications, between two groups (P>0.05). In both two groups, pain scores increased significantly at 6h, 12h and 24 h after surgery and gradually decreased at 48 h after surgery Pain scores in the EARS group were always lower than those in the conventional group at each time point respectively (P<0.05). The levels of Cor, NE and IL-6 were significantly increased in both two groups on day 1 after surgery, then gradually were decreased on day 3, and with lower levels in the EARS group at each time point respectively, compared with the conventional group (P<0.05).

Based on enhanced recovery after surgery principles, radical resection of hepatic hilar cholangiocarcinoma could effectively promote the rapid postoperative recovery of patients, and could reduce the incidence of postoperative complications, with better clinical outcome.