探讨结直肠癌患者采取单孔+1腹腔镜结直肠癌根治术治疗的有效性和安全性。

选取2021年1月至2023年12月收治的78例结直肠癌患者作为研究对象。采用随机数字表法将纳入者分为观察组（n=39，行单孔+1腹腔镜结直肠癌根治术）和对照组（n=39，行常规5孔腹腔镜结直肠癌根治术）。采用SPSS 25.0软件进行统计学分析。计数资料用百分率表示，比较采用χ²检验；符合正态分布的计量资料用（±s）表示，组间、组内比较分别行独立样本t检验、配对样本t检验；等级资料采用秩和检验。P<0.05为差异有统计学意义。

观察组患者切口长度、首次排气时间、下床活动时间、胃肠功能恢复时间及住院时间均明显短于对照组（P<0.05）；两组患者肿瘤最大直径、肿瘤远近端切缘距离及淋巴结清扫数目比较，差异无统计学意义（P>0.05）；术后1d、3d视觉模拟评分法（VAS）评分，观察组患者均比对照组更低（P<0.05）；肿瘤坏死因子（TNF-α）、C反应蛋白（CRP）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、去甲肾上腺素（NE）、皮质醇（COR）及肾上腺素（AD）指标水平比较，观察组患者均低于对照组（P<0.05）；切口感染、皮下气肿、吻合口出血、尿潴留、肠梗阻等并发症发生率比较，观察组患者低于对照组（P<0.05）。

对结直肠癌患者实施单孔+1腹腔镜结直肠癌根治术可有效缩短住院时间，减轻术后疼痛、炎症反应及应激反应，肿瘤根治效果确切，且降低并发症发生率，利于术后恢复，安全性高。

To explore the efficacy and safety of single-port plus one laparoscopic radical resection for colorectal cancer in patients with colorectal cancer.

A total of 78 patients with colorectal cancer admitted from January 2021 to December 2023 were selected as the research objects. They were divided into the observation group (n=39, undergoing single-port plus one laparoscopic radical resection for colorectal cancer) and the control group (n=39, undergoing conventional 5-port laparoscopic radical resection for colorectal cancer) using the random number table method. Statistical analysis was performed using SPSS 25.0 software. Enumeration data were expressed as percentages, and comparisons were made using the χ² test. Measurement data conforming to normal distribution were expressed as (±s); independent sample t test and paired sample t test were used for inter-group and intra-group comparisons, respectively. Rank sum test was used for ranked data. P<0.05 was considered statistically significant.

The incision length, time to first flatus, time to ambulation, gastrointestinal function recovery time, and hospital stay in the observation group were significantly shorter than those in the control group (P<0.05). There were no statistically significant differences between the two groups in terms of maximum tumor diameter, distance of proximal and distal tumor resection margins, or number of lymph nodes dissected (P>0.05). The Visual Analogue Scale (VAS) scores on the 1st and 3rd days after surgery in the observation group were lower than those in the control group (P<0.05). The levels of tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-8 (IL-8), norepinephrine (NE), cortisol (COR), and adrenaline (AD) in the observation group were all lower than those in the control group (P<0.05). The incidence of complications such as incision infection, subcutaneous emphysema, anastomotic bleeding, urinary retention, and intestinal obstruction in the observation group was lower than that in the control group (P<0.05).

The implementation of SILS+1 laparoscopic radical resection for colorectal cancer in patients with colorectal cancer can effectively shorten the hospital stay, reduce postoperative pain, inflammatory response, and stress response. It achieves a definite tumor radical effect, reduces the incidence of complications, promotes postoperative recovery, and has high safety.