To investigate the application effect of laparoscopic right hemicolectomy with ileocecal preservation (LISH) in hepatic flexure and transverse colon tumors.

A retrospective analysis was performed on the clinical data of 124 patients with hepatic flexure carcinoma and transverse colon tumors who underwent laparoscopic right hemicolectomy from February 2020 to February 2023. The patients were divided into the study group (n=56, receiving LISH) and the control group (n=68, receiving conventional laparoscopic right hemicolectomy) according to the surgical method. Data were analyzed using SPSS 20.0 statistical software. Measurement data (such as perioperative indicators and inflammatory factor levels) were expressed as (±s) and analyzed by independent sample t test; enumeration data (such as complications) were expressed as [cases (%)] and analyzed by χ² test; ordinal data (such as clinical stages) were analyzed by Rank Sum test. P<0.05 was considered statistically significant.

Compared with the control group, the study group had a shorter first exhaust time after surgery (P<0.05). Three days after surgery, the levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and C-reactive protein (CRP) in both groups increased significantly compared with those before surgery, but the levels in the study group were lower than those in the control group (P<0.05). Six months after surgery, the gastrointestinal myoelectric indices and quality of life scores in both groups were higher than those before surgery, and the study group showed higher levels than the control group (P<0.05). There was a statistically significant difference in the incidence of diarrhea between the two groups (P<0.05), while no significant difference was found in the disease-free survival rate (P>0.05).

LISH can promote the recovery of gastrointestinal function, reduce the inflammatory response and diarrhea incidence, and improve the quality of life in patients with hepatic flexure and transverse colon tumors, without affecting their short-term survival.