To compare the oncologic efficacy and risk of hepatectomy via Glisson pedicle sheath anatomical route in the treatment of primary liver cancer (PHC).

The medical data of 115 PHC patients who underwent hepatectomy from February 2018 to May 2021 were retrospectively collected, and were divided into intrathecal group (n=60 patients undergoing intrathecal resection with Glisson pedicle occlusion) and extrathecal group (n=55 patients undergoing intrathecal resection with Glisson pedicle occlusion) according to different operation methods. SPSS 23.0 statistical software was used to analyze the data. Surgical indicators were expressed as () and independent sample t test was used. The overall response rate was tested by Rank Sum test and the complications were tested by χ² test. Survival analysis was performed by Kaplan-Meier and Log-Rank test was performed. P<0.05 was considered statistically significant.

Operative time, ischemic line occurrence time and intraoperative blood loss in extrinsic group were lower than those in intrathecal group (P<0.05). There was no significant difference in length of hospital stay, total remission rate, total complication rate, 2-year postoperative recurrence rate and 2-year postoperative survival rate between 2 groups (P>0.05).

The two types of intrathecal resection via Glisson pedicle anatomical route have similar oncologic efficacy and short-term prognosis for PHC. However, compared with intrathecal resection via Glisson pedicle, intrathecal resection via Glisson pedicle can effectively reduce operative time and intraoperative bleeding.