Early glucolipid metabolism in obese patients with type 2 diabetes after laparoscopic sleeve gastrectomy

doi:10.3877/cma.j.issn.1674-3946.2023.01.008

Chinese Journal of Operative Procedures of General Surgery(Electronic Edition) ›› 2023, Vol. 17 ›› Issue (01): 23-26. doi: 10.3877/cma.j.issn.1674-3946.2023.01.008

• Original Article • Previous Articles Next Articles

Early glucolipid metabolism in obese patients with type 2 diabetes after laparoscopic sleeve gastrectomy

Mayongbin¹, Yusupujiang·Yimingjiang², Pierdiwasi³, Maimaiti·Yisireyili⁴, Yilihan·Yiming¹, Kelimu⁵, Aikebaier·Aili⁵^,^†()

^1. Department of Minimally Invasive Surgery，Hernia and Abdominal Wall Surgery，People’s Hospital of Xinjiang Uygur Autonomous Region，Urumqi Xinjiang Province 830001，China；Xinjiang Medical University Graduate School of Medicine，Urumqi Xinjiang Province 830054，China
^2. Xinjiang Medical University Graduate School of Medicine，Urumqi Xinjiang Province 830054，China
^3. Department of Minimally Invasive Surgery，Hernia and Abdominal Wall Surgery，People’s Hospital of Xinjiang Uygur Autonomous Region，Urumqi Xinjiang Province 830001，China
^4. Research Institute of General and Minimally Invasive Surgery，People’s Hospital of Xinjiang Uygur Autonomous Region，Urumqi Xinjiang Province 830001，China；Gastroesophageal Reflux Disease and Bariatric Metabolic Surgery Clinical Research Center of Xinjiang Uygur Autonomous Region，Urumqi Xinjiang Province 830001，China
^5. Department of Minimally Invasive Surgery，Hernia and Abdominal Wall Surgery，People’s Hospital of Xinjiang Uygur Autonomous Region，Urumqi Xinjiang Province 830001，China；Xinjiang Medical University Graduate School of Medicine，Urumqi Xinjiang Province 830054，China；Research Institute of General and Minimally Invasive Surgery，People’s Hospital of Xinjiang Uygur Autonomous Region，Urumqi Xinjiang Province 830001，China；Gastroesophageal Reflux Disease and Bariatric Metabolic Surgery Clinical Research Center of Xinjiang Uygur Autonomous Region，Urumqi Xinjiang Province 830001，China

Received:2022-01-10 Online:2023-02-26 Published:2023-01-05
Contact: Aikebaier·Aili
Supported by:
National Natural Science Foundation of China(82060166); Xinjiang Uygur Autonomous Region Regional Collaborative Innovation Special（Shanghai Cooperative Science and Technology Partner Program and International Science and Technology Cooperation Program）(2020E01014); Tianchi hundred talents Plan Project for the introduction of High-level talents in Xinjiang Uygur Autonomous region(201939)

Abstract

Abstract:

Objective

To investigate the effect of early glycolipid metabolism in obese patients with type 2 diabetes after LSG surgery.

Methods

A retrospective analysis was performed on 23 patients who were obese and complicated with type 2 diabetes and underwent LSG surgery from May 2017 to September 2020. The relevant indexes of weight，diabetes and blood lipids before surgery，1，3 and 6 months after surgery were collected. SPSS 23.0 was used for statistical analysis of the data，and the measurement data were presented as（

x ˉ

±s）with normal distribution. Those who did not conform to normal distribution were represented by［median（P25，P75）］. Those who did not conform to normal distribution before and after surgery were analyzed by paired T-test，and those who did not were analyzed by Wilcoxon sign rank sum test. Pearson correlation analysis was used for correlation analysis，and P<0.05 was considered statistically significant.

Results

The 23 obese patients with type 2 diabetes mellitus had differences in preoperative weight，glycated hemoglobin（HbA1c），fasting blood glucose（GLU），high density lipoprotein（HDL），and insulin resistance index（HOMA-IR）compared with the above indicators 1，3 and 6 months after surgery There was statistical significance（P<0.05）. Body weight and BMI were significantly reduced，GLU and HbA1c were normal，and HDL was increased，with statistical significance（P<0.05）. There was no significant difference in serum lipid indexes CHDL，total cholesterol（CHDL），TG，and low density lipoprotein and other indicators（LDL）3 and 6 months after surgery（P>0.05）.

Conclusions

The indexes of body weight，blood glucose and HDL were significantly improved in the early postoperative period of patients with LSG.

Key words: Obesity, Diabetes Mellitus，Type 2, Gastrectomy, Lipid Metabolism

Mayongbin, Yusupujiang·Yimingjiang, Pierdiwasi, Maimaiti·Yisireyili, Yilihan·Yiming, Kelimu, Aikebaier·Aili. Early glucolipid metabolism in obese patients with type 2 diabetes after laparoscopic sleeve gastrectomy[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2023, 17(01): 23-26.

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References 19

[1]	李贵芳，张君宜，梅芳芸，等. 腹腔镜下袖状胃切除术治疗不同血脂水平肥胖患者的疗效研究［J］.同济大学学报（医学版），2020，41（02）：178-184.
[2]	戚晓阳，林煌，龚宇，等. 袖状胃切除术与食管十二指肠吻合伴全胃切除术对肥胖合并2型糖尿病大鼠模型糖代谢影响的对比研究［J］. 腹腔镜外科杂志，2021，26（03）：161-164，176.
[3]	买买提·依斯热依力，阿巴伯克力·乌斯曼，艾克拜尔·艾力，等. 腹腔镜袖状胃切除术治疗肥胖合并2型糖尿病的临床研究［J/CD］. 中华普外科手术学杂志（电子版），2021，15（05）：497-500.
[4]	Felsenreich DM，Bichler C，Gachabayov M，et al. Sleeve Gastrectomy：Surgical Technique，Outcomes，and Complications［J］. Surgi Technol Int，2020，36：63-69.
[5]	鲁旭，鲁宏艺，钱赢，等. 重度肥胖患者应用腹腔镜下袖状胃切除术与胃旁路术治疗前后肺功能及血脂水平变化分析［J/CD］. 中华普外科手术学杂志（电子版），2018，12（03）：242-245.
[6]	赛米· 赛麦提，买买提·依斯热依力，艾克拜尔·艾力. 肥胖与2型糖尿病关系的研究进展［J/CD］. 中华肥胖与代谢病电子杂志，2020，6（02）：130-134.
[7]	张耿，占达良，邓炳取，等. 老年2型糖尿病患者尿路感染与血糖控制的相关性分析［J］. 中华医院感染学杂志，2017，27（20）：4661-4663，4667.
[8]	Vekic J，Zeljkovic A，Stefanovic A，et al. Obesity and dyslipidemia［J］. Metabolism，2019，92：71-81.
[9]	智杰武. 2型糖尿病血糖与血脂相关性分析［J/CD］. 临床医药文献电子杂志，2018，5（54）：32.
[10]	李冲，郑丽丽，翟绍忠，等. 2型糖尿病患者24h尿糖与全天血糖谱的相关性分析［J］. 中国临床医学，2017，24（04）：554-559.
[11]	Heffron SP，Parikh A，Volodarskiy A，et al. Changes in Lipid Profile of Obese Patients Following Contemporary Bariatric Surgery：A Meta-Analysis［J］. Am J Med，2016，129（9）：952-959.
[12]	Zhang Y，Zhu C，Wen X，et al. Laparoscopic sleeve gastrectomy improves body composition and alleviates insulin resistance in obesity related acanthosis nigricans［J］. Lipids Health Dis，2017，16（1）：209.
[13]	Elgenaied I，Elsherif M，Elhag W，et al. A390 Long term follow up to evaluate diabetes remission and risk of relapse in patients with type II diabetes（T2DM）following Laparoscopic sleeve gastrectomy（LSG）［J］. Surgery for Obesity and Related Diseases，2019，15（10）：S158.
[14]	秦天实. LSG术后非糖尿病肥胖症患者血脂、血尿酸的变化及意义［D］. 新疆：石河子大学，2020：1-34.
[15]	Morshed G，Fathy SM. Impact of post-laparoscopic sleeve gastrectomy weight loss on C-reactive protein，lipid profile and CA-125 in morbidly obese women［J］. Wideochir Inne Tech Maloinwazyjne，2016，10（4）：521-526.
[16]	Yang J，Wang C，Cao G，et al. Long-term effects of laparoscopic sleeve gastrectomy versus roux-en-Y gastric bypass for the treatment of Chinese type 2 diabetes mellitus patients with body mass index 28-35 kg/m2［J］. BMC Surg，2015，15：88.
[17]	韩晓凯. 袖状胃切除术治疗2型糖尿病作用及机制的研究［D］. 石家庄：河北医科大学，2017：1-68.
[18]	Erol V，Yılmaz TH，Tuncali B，et al. Changes in serum lipid levels after laparoscopic sleeve gastrectomy in morbidly obese dyslipidemic and normolipidemic patients［J］. Acta Chir Belg，2018，118（4）：233-238.
[19]	张忠涛，张鹏. 腹腔镜减重与代谢外科治疗现状与发展［J/CD］. 中华普外科手术学杂志（电子版），2020，14（02）：109-113

项目	术前	术后1个月
体重(kg)	126.0±23.4	111.1±22.7^a
BMI(kg/m²)	43.1（36.6，49.6）	38.1（31.8，44.3）^a
GLU(mmol/L)	8.3（5.7，10.5）	4.8(4.4,5.4)^a
HbA1c(%)	8.6(6.0,9.9)	6.5(5.7,7.5)^a
HOMA-IR	5.4(4.5,18.3)	3.7(1.9,6.6)^a
TC(mmol/L)	5.1（4.3，5.7）	4.4(3.7,5.1)^a
TG(mmol/L)	1.9(1.3,3.9)	1.4(1.2,1.6)^a
HDL-C(mmol/L)	1.0±0.2	0.9±0.2
LDL-C(mmol/L)	2.9±1.1	2.8±0.8
项目	术后3个月	术后6个月
体重(kg)	97.3±17.3^b	87.4±14.4^c
BMI(kg/m²)	33.5±5.4^b	30.5±4.6^c
GLU(mmol/L)	4.4±1.1^b	4.1（3.2，4.4）^c
HbA1c(%)	5.5±1.4^b	4.9±1.7^c
HOMA-IR	1.6(1.2,4.3)^b	1.4（0.9，1.8）^c
TC(mmol/L)	4.6(3.9,5.3)	4.7±0.8
TG(mmol/L)	1.1(0.9,1.4)^b	1.0（0.8，1.2）^c
HDL-C(mmol/L)	1.1±0.2^b	1.3±0.2^c
LDL-C(mmol/L)	2.6±0.6	2.6±0.6

项目	术前	术后1个月
体重(kg)	126.0±23.4	111.1±22.7^a
BMI(kg/m²)	43.1（36.6，49.6）	38.1（31.8，44.3）^a
GLU(mmol/L)	8.3（5.7，10.5）	4.8(4.4,5.4)^a
HbA1c(%)	8.6(6.0,9.9)	6.5(5.7,7.5)^a
HOMA-IR	5.4(4.5,18.3)	3.7(1.9,6.6)^a
TC(mmol/L)	5.1（4.3，5.7）	4.4(3.7,5.1)^a
TG(mmol/L)	1.9(1.3,3.9)	1.4(1.2,1.6)^a
HDL-C(mmol/L)	1.0±0.2	0.9±0.2
LDL-C(mmol/L)	2.9±1.1	2.8±0.8
项目	术后3个月	术后6个月
体重(kg)	97.3±17.3^b	87.4±14.4^c
BMI(kg/m²)	33.5±5.4^b	30.5±4.6^c
GLU(mmol/L)	4.4±1.1^b	4.1（3.2，4.4）^c
HbA1c(%)	5.5±1.4^b	4.9±1.7^c
HOMA-IR	1.6(1.2,4.3)^b	1.4（0.9，1.8）^c
TC(mmol/L)	4.6(3.9,5.3)	4.7±0.8
TG(mmol/L)	1.1(0.9,1.4)^b	1.0（0.8，1.2）^c
HDL-C(mmol/L)	1.1±0.2^b	1.3±0.2^c
LDL-C(mmol/L)	2.6±0.6	2.6±0.6

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