Early glucolipid metabolism in obese patients with type 2 diabetes after laparoscopic sleeve gastrectomy

doi:10.3877/cma.j.issn.1674-3946.2023.01.008

Chinese Journal of Operative Procedures of General Surgery(Electronic Edition) ›› 2023, Vol. 17 ›› Issue (01): 23-26. doi: 10.3877/cma.j.issn.1674-3946.2023.01.008

• Original Article • Previous Articles Next Articles

Early glucolipid metabolism in obese patients with type 2 diabetes after laparoscopic sleeve gastrectomy

Mayongbin¹, Yusupujiang·Yimingjiang², Pierdiwasi³, Maimaiti·Yisireyili⁴, Yilihan·Yiming¹, Kelimu⁵, Aikebaier·Aili⁵^,^†()

^1. Department of Minimally Invasive Surgery，Hernia and Abdominal Wall Surgery，People’s Hospital of Xinjiang Uygur Autonomous Region，Urumqi Xinjiang Province 830001，China；Xinjiang Medical University Graduate School of Medicine，Urumqi Xinjiang Province 830054，China
^2. Xinjiang Medical University Graduate School of Medicine，Urumqi Xinjiang Province 830054，China
^3. Department of Minimally Invasive Surgery，Hernia and Abdominal Wall Surgery，People’s Hospital of Xinjiang Uygur Autonomous Region，Urumqi Xinjiang Province 830001，China
^4. Research Institute of General and Minimally Invasive Surgery，People’s Hospital of Xinjiang Uygur Autonomous Region，Urumqi Xinjiang Province 830001，China；Gastroesophageal Reflux Disease and Bariatric Metabolic Surgery Clinical Research Center of Xinjiang Uygur Autonomous Region，Urumqi Xinjiang Province 830001，China
^5. Department of Minimally Invasive Surgery，Hernia and Abdominal Wall Surgery，People’s Hospital of Xinjiang Uygur Autonomous Region，Urumqi Xinjiang Province 830001，China；Xinjiang Medical University Graduate School of Medicine，Urumqi Xinjiang Province 830054，China；Research Institute of General and Minimally Invasive Surgery，People’s Hospital of Xinjiang Uygur Autonomous Region，Urumqi Xinjiang Province 830001，China；Gastroesophageal Reflux Disease and Bariatric Metabolic Surgery Clinical Research Center of Xinjiang Uygur Autonomous Region，Urumqi Xinjiang Province 830001，China

Received:2022-01-10 Online:2023-02-26 Published:2023-01-05
Contact: Aikebaier·Aili
Supported by:
National Natural Science Foundation of China(82060166); Xinjiang Uygur Autonomous Region Regional Collaborative Innovation Special（Shanghai Cooperative Science and Technology Partner Program and International Science and Technology Cooperation Program）(2020E01014); Tianchi hundred talents Plan Project for the introduction of High-level talents in Xinjiang Uygur Autonomous region(201939)

Abstract

Abstract:

Objective

To investigate the effect of early glycolipid metabolism in obese patients with type 2 diabetes after LSG surgery.

Methods

A retrospective analysis was performed on 23 patients who were obese and complicated with type 2 diabetes and underwent LSG surgery from May 2017 to September 2020. The relevant indexes of weight，diabetes and blood lipids before surgery，1，3 and 6 months after surgery were collected. SPSS 23.0 was used for statistical analysis of the data，and the measurement data were presented as（

x ˉ

±s）with normal distribution. Those who did not conform to normal distribution were represented by［median（P25，P75）］. Those who did not conform to normal distribution before and after surgery were analyzed by paired T-test，and those who did not were analyzed by Wilcoxon sign rank sum test. Pearson correlation analysis was used for correlation analysis，and P<0.05 was considered statistically significant.

Results

The 23 obese patients with type 2 diabetes mellitus had differences in preoperative weight，glycated hemoglobin（HbA1c），fasting blood glucose（GLU），high density lipoprotein（HDL），and insulin resistance index（HOMA-IR）compared with the above indicators 1，3 and 6 months after surgery There was statistical significance（P<0.05）. Body weight and BMI were significantly reduced，GLU and HbA1c were normal，and HDL was increased，with statistical significance（P<0.05）. There was no significant difference in serum lipid indexes CHDL，total cholesterol（CHDL），TG，and low density lipoprotein and other indicators（LDL）3 and 6 months after surgery（P>0.05）.

Conclusions

The indexes of body weight，blood glucose and HDL were significantly improved in the early postoperative period of patients with LSG.

Key words: Obesity, Diabetes Mellitus，Type 2, Gastrectomy, Lipid Metabolism

Mayongbin, Yusupujiang·Yimingjiang, Pierdiwasi, Maimaiti·Yisireyili, Yilihan·Yiming, Kelimu, Aikebaier·Aili. Early glucolipid metabolism in obese patients with type 2 diabetes after laparoscopic sleeve gastrectomy[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2023, 17(01): 23-26.

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References 19

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项目	术前	术后1个月
体重(kg)	126.0±23.4	111.1±22.7^a
BMI(kg/m²)	43.1（36.6，49.6）	38.1（31.8，44.3）^a
GLU(mmol/L)	8.3（5.7，10.5）	4.8(4.4,5.4)^a
HbA1c(%)	8.6(6.0,9.9)	6.5(5.7,7.5)^a
HOMA-IR	5.4(4.5,18.3)	3.7(1.9,6.6)^a
TC(mmol/L)	5.1（4.3，5.7）	4.4(3.7,5.1)^a
TG(mmol/L)	1.9(1.3,3.9)	1.4(1.2,1.6)^a
HDL-C(mmol/L)	1.0±0.2	0.9±0.2
LDL-C(mmol/L)	2.9±1.1	2.8±0.8
项目	术后3个月	术后6个月
体重(kg)	97.3±17.3^b	87.4±14.4^c
BMI(kg/m²)	33.5±5.4^b	30.5±4.6^c
GLU(mmol/L)	4.4±1.1^b	4.1（3.2，4.4）^c
HbA1c(%)	5.5±1.4^b	4.9±1.7^c
HOMA-IR	1.6(1.2,4.3)^b	1.4（0.9，1.8）^c
TC(mmol/L)	4.6(3.9,5.3)	4.7±0.8
TG(mmol/L)	1.1(0.9,1.4)^b	1.0（0.8，1.2）^c
HDL-C(mmol/L)	1.1±0.2^b	1.3±0.2^c
LDL-C(mmol/L)	2.6±0.6	2.6±0.6

项目	术前	术后1个月
体重(kg)	126.0±23.4	111.1±22.7^a
BMI(kg/m²)	43.1（36.6，49.6）	38.1（31.8，44.3）^a
GLU(mmol/L)	8.3（5.7，10.5）	4.8(4.4,5.4)^a
HbA1c(%)	8.6(6.0,9.9)	6.5(5.7,7.5)^a
HOMA-IR	5.4(4.5,18.3)	3.7(1.9,6.6)^a
TC(mmol/L)	5.1（4.3，5.7）	4.4(3.7,5.1)^a
TG(mmol/L)	1.9(1.3,3.9)	1.4(1.2,1.6)^a
HDL-C(mmol/L)	1.0±0.2	0.9±0.2
LDL-C(mmol/L)	2.9±1.1	2.8±0.8
项目	术后3个月	术后6个月
体重(kg)	97.3±17.3^b	87.4±14.4^c
BMI(kg/m²)	33.5±5.4^b	30.5±4.6^c
GLU(mmol/L)	4.4±1.1^b	4.1（3.2，4.4）^c
HbA1c(%)	5.5±1.4^b	4.9±1.7^c
HOMA-IR	1.6(1.2,4.3)^b	1.4（0.9，1.8）^c
TC(mmol/L)	4.6(3.9,5.3)	4.7±0.8
TG(mmol/L)	1.1(0.9,1.4)^b	1.0（0.8，1.2）^c
HDL-C(mmol/L)	1.1±0.2^b	1.3±0.2^c
LDL-C(mmol/L)	2.6±0.6	2.6±0.6

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