Pancreatic ductal adenocarcinoma is one of the most malignant tumors with poor prognosis，which usually accompanies with regional lymph node and distant metastasis in early stage. The five-year survival rate is less than 6%，and the primary route of metastasis is lymph node metastasis. Lymph node metastasis is the key point of factors resulting in poor prognosis. How to figure out this problem，which has been the hotpot and difficulty in hepatopancreatobiliary surgery. At present，the standard lymph node dissection has been recognized. However，the clinical application of extended Lymphadenectomy remains controversial. Based on the 13 years clinical data from our department，we demonstrated that pancreaticoduodenectomy with extended lymphadenectomy contributes to remove residual tumor tissue and positive lymph nodes with metastasis，reduce recurrence，delay progression and improve the overall survival time.