To analyze the long-term outcome of endoscopic dissection in the treatment of early gastric cancer and high-grade intraepithelial neoplasia.

The clinical data of 68 patients with early gastric cancer and high-grade intraepithelial neoplasia from May 2014 to May 2016 were analyzed retrospectively. 34 patients were divided into the endoscopy group who underwent endoscopic dissection, while 34 patients were divided into the laparotomy group who received laparotomy. Statistical analysis were performed by using SPSS23.0 software. The data of quality of life (GQOLI-74) score was expressed as (±s), and were examined by using t test; The incidence of complication and tumor recurrence were examined by using χ² test; The survival were analyzed by using Kaplan-meier Law test. A P value of <0.05 was considered as statistically significant difference.

There were no significant difference between the endoscopy and the laparotomy group in terms of the cure rate of gastric cancer, the rate of en bloc resection, the rate of complete resection, and the incidence of complications (P>0.05); Comparing the 1-year, 3-year, and 5-year survival, 5-year survival of 94.1% were achieved in both two groups (P>0.05); Compared with the laparotomy group, higher GQOLI-74 score was observed in the endoscopy group (P<0.05).

The clinical outcome including the 5-year survival of the endoscopic dissection are similar to the laparotomy in the treatment of early gastric cancer and high-grade intraepithelial neoplasia, however the former has obvious advantage in improving the quality of life.