To investigate the effect of early regulation of intestinal flora on early recovery, stress and immune function in patients undergoing radical resection of colon cancer.

The clinical data of 85 patients underwent elective radical resection of colon cancer in our hospital from January 2017 to December 2018 were retrospectively analyzed. The patients who were given intestinal flora regulation 2 weeks before operation were divided into intervention group (40 cases) and those without intestinal flora regulation were divide into control group (45 cases). SPSS24.0 was used for data analysis. Clinical indicators, number of intestinal flora, immune function and inflammatory response indicators were described by (±s). Independent sample t test was used for inter-group comparison, paired sample t test was used for intra-group comparison, P<0.05 indicated statistically significant difference.

The fever time of intervention group was shorter than that of control group (P<0.05). There was no significant difference in the number of four kinds of intestinal flora in the intervention group compared with that in the control group 1d before the operation (P>0.05); The number of bifidobacteria and lactobacillus in feces in the intervention group was significantly increased (P<0.05), and the number of escherichia coli and enterococci was significantly decreased (P<0.05); The number of bifidobacteria and Lactobacillus in the intervention group was significantly more than that in the control group on the 3rd day after operation, while the number of Escherichia coli and Enterococcus was significantly less than that in the control group (P<0.05). The levels of IL-6 and CRP in the intervention group were significantly lower than those in the control group on the 3rd day after operation (P<0.05).

Early regulation of intestinal flora can effectively improve the intestinal flora disorder after colon cancer surgery and reduce postoperative stress.