A male patient of 72 years old was admitted to hospital due to intermittent abdominal distension for 2 months. He had the previous history of open appendectomy for appendicitis. Endoscopic examination found colonic circumferential mass 70cm from the anal, with pathological result of colonic adenocarcinoma. Colonic mass was found at hepatic flexure of colon with T4aN1M0 staging by using colonic enhanced CT. Laparoscopic radical right hemicolectomy (D3) was performed as following: Adhesions between greater omentum, abdominal wall and right hemicolon were dissected firstly and the lateral right mesocolon was separated at the level of hepatic flexure of colon. Then, the medial approach was used to dissect the surgical trunk. Finally, End-to-side ileocolic anastomosis was completed with upper abdomen incision.