Minimally invasive surgery has been developed in laparoscopic platform for 30 years, and laparoscopic technology has entered a mature stage in the field of gastrointestinal surgery. Development of laparoscopic surgery in recent years was based on two points: the further standardization and popularization of surgical approach and anatomy; the innovation and development of display plat from (i.e, Three-dimensional display, 4K Ultra HD). Starting point of Caudal-to-Medial approach laparoscopic right hemicolectomy was from the posterior space of ileocecal junction. Dissection of posterior space of right mesocolon was performed, and lymph nodes dissection of the vascular root was performed combined with traditional medial approach. Caudal-to-Medial approach could assist the surgeon to complete the anatomizing the right mesocolon, and it also could assist to complete the extension of posterior space of right hemicolon. Caudal-to-Medial approach could be one of the preferred surgical approaches for surgeons.