Investigate the short-term efficacy and long-term prognosis of patients with portal vein-involved pancreatic cancer after radical resection.

From July 2012 to October 2015, retrospective analysis of 85 cases of portal vein-involved pancreatic cancer were performed, including 45 cases in combined group and 40 cases in conventional group according to surgical treatments. Briefly, patients in the combined group received radical pancreatic cancer resection combined with portal vein resection, while the conventional group received palliative bypass surgery. The operation condition, short-term therapeutic effect, incidence of complications and survival rate of patients in two groups were compared, and the quality of life of patients were evaluated in both two groups before and after surgery. Statistical analysis were performed by using SPSS 21.0 software. Measurement data, such as quality of life indicators were expressed as(±s), and were examined by using independent t test. Count data such as therapeutic effects were examined by chi square test. A P value <0.05 was considered as statistically significant difference.

There were no significant difference between two groups in terms of operative time and incidence of complications (P>0.05). Intraoperative bleeding volume and portal vein occlusion time in the combined group were significantly more than those in the conventional group respectively (P<0.05). The effective rate of the combined group(93.3%) was significantly higher than that in the conventional group(77.5%) (P<0.05). The 1-year recurrence-free survival rate and 1-year survival rate of the combined group were significantly better than those of the conventional group respectively (P<0.05). There was no significant difference between the two groups in terms of 3-year recurrence-free survival rate and 3-year survival rate (P>0.05). After treatment, the quality of life scores of both groups were significantly improved, and the combined group was significantly better than the conventional group (P<0.05).

Portal vein resection combined with radical pancreatic cancer resection in treatment of pancreatic cancer with portal vein involvement could effectively relieve clinical symptoms and could improve the quality of life, with fewer complications and better short-term effect.