To explore the relationship between prophylactic antibiotics and breast implants infection rates after breast cancer surgery with immediate reconstruction by breast prosthesis.

From February 2017 to October 2018, clinical data of patients underwent breast cancer surgery with immediate reconstruction by breast prosthesis were analyzed retrospectively. According to usage of antibiotics, the patients were divided into 2 groups: 52 cases in <24 h group with application of antibiotics within 24 hours and 64 cases in >24 h group with application more than 24 hours or till the patients′body temperature was under 37.5℃. The statistical analysis was performed by using the SPSS19.0 software package, Tumor size, operation time, body temperature, incision level A healing time and other measurement datas were presented as mean+ standard deviation and were examined by using t test. Infection rate were expressed as %, and were compared with χ² test or Fisher test. P<0.05 was considered as significant difference.

The breast implants infection rates within 30 days and the breast implants infection rates at any time in >24 h group and in <24 h group were 12.50%、19.23% and 15.63%、21.15% respectively, with no statistically significant difference between two groups respectively (P>0.05); the time of Surgical incision healing reached Grade A in>24 h group and <24 h group were (18.7±3.4) d and (18.4±4.4) d, with no statistically significant difference between two groups (P>0.05).

The perioperative long-term application of antibiotics could not further reduce the breast implants infection rateafter breast cancer surgery with immediate reconstruction by breast prosthesis.