Correlation between cognitive dysfunction and 5-serotonin receptor 3B subunit in patients with colon cancer after curative resection and its effect on prognosis

doi:10.3877/cma.j.issn.1674-3946.2019.02.017

Abstract

Abstract:

Objective

To investigate the relationship between cognitive dysfunction and the 5-serotonin receptor 3B subunit in patients with colon cancer after curative resection and its effect on the prognosis.

Methods

From May 2013 to January 2017, 86 patients with colon cancer were retrospectively collected in our hospital. General anesthesia of laparoscopic surgery for colorectal cancer were preformed in all the patients. According to the presence of cognitive dysfunction in the patients after surgery, the patients were divided into a POCD group (cognitive dysfunction, n=28) and a control group (without cognitive impairment, n=58). The data analysis was completed by SPSS22.0. Independent t test was used in the two groups of patients’ mental health. The gene polymorphism analysis of 5-serotonin receptor 3B subunit was analyzed by chi square test. The risk factors of POCD in colon cancer patients after curative resection were analyzed by multiple factor logistic regression analysis. P<0.05 indicated that the difference was statistically significant.

Results

The polymorphic distribution of rs10789970 was found between the POCD group and the control group, and the proportion of the wild type CC in the POCD group was significantly higher than that of the control group (P<0.05). The MMSE of patients with POCD and CC, CT and TT of rs10789970 were 15.7±3.8、17.8±3.8 and 20.0±2.8, and the difference was statistically significant (P=0.000). Multiple factor logistic regression analysis showed that the wild type CC of rs10789970 was an independent risk factor for POCD in patients [1.21(1.02~1.40), P=0.002]. There were no significant difference in self-rating anxiety score and self-rating depression score between the two groups (P>0.05). When compared with the control group, the self-rating anxiety score and self-rating depression score in the POCD group were higher than that of the control group on the third day after the operation (P<0.05). When compared with the control group, the anal exhaust time and hospitalization time in the POCD group were significantly prolonged (P<0.05).

Conclusion

The occurrence of postoperative cognitive dysfunction in patients with colon cancer after curative resection is related to the polymorphism distribution of rs10789970, which can deteriorate the mental health of the patients and affect the postoperative rehabilitation.

Key words: Colonic neoplasms, Cognition disorders, Receptors, serotonin, Rehabilitation, ental status schedule

Zhan Liu, Yuntao Li, Shihong Li, Feiwu Long, Hailiang Ren, Jianhui Gu. Correlation between cognitive dysfunction and 5-serotonin receptor 3B subunit in patients with colon cancer after curative resection and its effect on prognosis[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2019, 13(02): 162-165.

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References 20

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类别	例数	性别(男)	年龄(岁)	TNM分期	分化程度	肿瘤类型
类别	例数	性别(男)	年龄(岁)	Ⅱ/Ⅲ	高/中/低	粘液腺癌/腺癌
POCD组	28	16	56.2±3.4	15/13	18/8/5	5/23
对照组	58	35	57.2±3.6	32/26	33/15/10	9/49
t/χ²值	?	0.080	1.172	0.020	0.093	0.076
P值	?	0.777	0.244	0.889	0.954	0.783
类别	例数	病变部位
类别	例数	升结肠/横结肠/降结肠/乙状结肠/直肠
POCD组	28	7/5/3/6/7
对照组	58	15/10/5/14/14
t/χ²值	?	0.164
P值	?	0.997

类别	例数	性别(男)	年龄(岁)	TNM分期	分化程度	肿瘤类型
类别	例数	性别(男)	年龄(岁)	Ⅱ/Ⅲ	高/中/低	粘液腺癌/腺癌
POCD组	28	16	56.2±3.4	15/13	18/8/5	5/23
对照组	58	35	57.2±3.6	32/26	33/15/10	9/49
t/χ²值	?	0.080	1.172	0.020	0.093	0.076
P值	?	0.777	0.244	0.889	0.954	0.783
类别	例数	病变部位
类别	例数	升结肠/横结肠/降结肠/乙状结肠/直肠
POCD组	28	7/5/3/6/7
对照组	58	15/10/5/14/14
t/χ²值	?	0.164
P值	?	0.997

组别	例数	rs1176744	rs2276305	rs10789970
组别	例数	GG/GA/AA	GG/GA/AA	CC/TC/TT
POCD组	28	2/6/20	1/6/21	13/11/4
对照组	58	6/17/35	4/15/39	12/32/14
χ²值	?	1.010	0.674	6.711
P值	?	0.604	0.714	0.035

组别	例数	rs1176744	rs2276305	rs10789970
组别	例数	GG/GA/AA	GG/GA/AA	CC/TC/TT
POCD组	28	2/6/20	1/6/21	13/11/4
对照组	58	6/17/35	4/15/39	12/32/14
χ²值	?	1.010	0.674	6.711
P值	?	0.604	0.714	0.035

因素	B	S.E.	Wald
年龄≥60岁	1.181	0.435	1.4623
TNM分期为Ⅲ期	2.205	0.352	1.912
rs10789970(CC)	2.431	0.461	2.574
rs1176744(GG)	0.446	0.142	0.146
rs2276305(GG)	0.231	0.081	0.091
男性	0.843	0.434	0.782
手术时间≥120 min	0.141	0.523	0.982
术中出血量≥500 ml	0.374	0.419	0.563
淋巴结清扫数目≥20枚	0.382	0.441	0.632
因素	OR(95%CI)	P值
年龄≥60岁	1.14(0.93～1.35)	0.083
TNM分期为Ⅲ期	1.25(1.03～1.47)	0.002
rs10789970(CC)	1.21(1.02～1.40)	0.002
rs1176744(GG)	1.07(0.89～1.25)	0.725
rs2276305(GG)	1.01(0.91～1.11)	0.827
男性	1.16(0.78～4.34)	0.533
手术时间≥120 min	1.21(0.82～2.40)	0.402
术中出血量≥500 ml	1.08(0.76～3.29)	0.284
淋巴结清扫数目≥20枚	1.09(0.81～3.28)	0.178

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