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Chinese Journal of Operative Procedures of General Surgery(Electronic Edition) ›› 2025, Vol. 19 ›› Issue (02): 184-187. doi: 10.3877/cma.j.issn.1674-3946.2025.02.018.

• Original Articles • Previous Articles    

The application effect of neoadjuvant chemotherapy combined with breast conserving surgery and modified radical surgery in the treatment of stage Ⅱ and Ⅲ breast cancer respectively

Youxin He1, Linhui Han1, Heqing Yang1,()   

  1. 1.Department of General Surgery, Qinhuangdao Second Hospital, Qinhuangdao Hebei Province 066600, China
  • Received:2023-10-07 Online:2025-04-26 Published:2025-02-25
  • Contact: Heqing Yang

Abstract:

Objective

To explore the effect of neoadjuvant chemotherapy combined with breast conserving surgery and modified radical surgery in the treatment of stage Ⅱ and Ⅲ breast cancer respectively.

Methods

Clinical data of 99 patients with breast cancer admitted from January 2017 to December 2019 were retrospectively analyzed, and divided into control group (neoadjuvant chemotherapy combined with modified radical surgery, n=49 cases) and observation group (neoadjuvant chemotherapy combined with breastconserving surgery, n=50 cases) according to different treatment methods.SPSS 25.0 software was used to process the data.Perioperative indicators, serum tumor markers and other measurement data were expressed as(x±s), and independent sample t test was used.The incidence of postoperative complications and recurrence survival were analyzed by Chi-square test.P<0.05 was considered statistically significant.

Results

There was no significant difference in operation time between the two groups (P>0.05).The duration of hospitalization and drainage tube removal in observation group was shorter than that in control group, and the amount of intraoperative blood loss was lower than that in control group (P<0.05).The levels of carbohydrate antigen (CA)125 and carcinoembryonic antigen (CEA) in 2 groups were decreased after surgery, but there was no statistical significance between groups (P>0.05).The total incidence of postoperative complications in observation group (4.0%) was lower than that in control group (18.4%), and the difference was statistically significant(P<0.05).There was no significant difference in recurrence rate and survival rate between observation group and control group within 3 years after operation (P>0.05).

Conclusion

Compared with modified radical surgery, breast-conserving surgery has a similar therapeutic effect for breast cancer patients, but the latter has less intraoperative blood loss, shorter hospitalization and drainage tube removal time, and a lower incidence of postoperative complications.

Key words: Breast Cancer, Modified Radical Mastectomy, Breast Conserving Surgery, Neoadjuvant Chemotherapy

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