To investigate the clinical effect of laparoscopic hepatectomy（LH）combined with radiofrequency ablation（RFA）in the treatment of hepatocellular carcinoma（HCC）with microvascular invasion（MVI）.

Twenty-eight MVI patients with HCC who received conventional LH treatment and RFA treatment with LH combination section from June 2018 to June 2020 were retrospectively selected and divided into conventional group and combination group according to treatment method. Statistical software SPSS 22.0 was used to analyze the measurement data of perioperative relevant indicators and liver function indicators of the two groups（

The blood drainage in the combined group was significantly lower than that in the conventional group 24 hours after operation，and the hospitalization cost was significantly increased（P<0.05）. There was no interaction between time and method at ALB，AST，TBILand ALT levels（P>0.05），and the main effect of time was significant at ALB，AST，TBIL and ALT levels（P<0.05），while the main effect of method was not significant at ALB，AST，TBIL and ALT levels（P>0.05）. There was no significant difference in the total incidence of postoperative complications between the two groups（32.1%vs.21.4%）（P > 0.05）. During the follow-up period，Kaplan-Meier analysis showed that the cumulative overall survival rate（71.4%vs.50.0%）and disease-free survival rate（64.3%vs.42.9%）of the combined group were significantly higher than those of the conventional group，and the difference was statistically significant（Log-Rank χ² =4.099，4.710，P=0.043，0.030）.

Although the hospitalization cost of LH combined with sectional RFA for HCC accompanied by MVI is slightly higher，it is safe and feasible，and can guarantee the postoperative liver function of patients to the greatest extent and improve the prognosis of patients.