To study the effects of antibiotic treatment on intestinal bacterial translocation and intestinal mucosal barrier function in patients after radical gastrectomy for gastric cancer.

A retrospective analysis was conducted on the data of 100 patients undergoing radical gastrectomy for gastric cancer from June 2020 to June 2022. They were divided into an experimental group (50 cases treated with antibiotics) and a natural recovery group (50 cases treated without antibiotics) based on whether antibiotics were used. SPSS 22.0 statistical software was used to process the data. Quantitative data such as the number of gut microbiota, intestinal mucosal permeability indicators, stress levels, plasma D-lactate, diamine oxidase (DAO) levels, plasma glutamine (Gln) content, and gastrointestinal motility related indicators were expressed using () and independent sample t tests were used. The occurrence of complications and the number of bacterial DNA testing types in the blood were counted using χ² analysis showed a statistically significant difference of P<0.05.

There were significant differences between the two groups in blood bacterial DNA, the number of Gut microbiota, intestinal mucosal permeability, stress level, plasma D-lactic acid, DAO level, plasma Gln content and intestinal motility (P<0.05). The positive number of blood bacterial cultures in the test group was 0, while in the natural recovery group was 14.0%; The number of Gut microbiota in the test group was better than that in the natural recovery group (P<0.05), and the Lactulose/Mannitol (L/M) value and plasma endotoxin (LPS) value were significantly increased. the total count of white blood cell (WBC), C-reactive protein (CRP) and Calcitonin (PCT) in the natural recovery group were higher than those in the test group (P<0.05). In addition, the exhaust time, diarrhea time, and medication frequency due to diarrhea in the experimental group were all lower than those in the natural recovery group (P<0.05). The total incidence of complications in the test group (10.0%) was lower than that in the natural recovery group (16.0%), but the difference was not statistically significant (P>0.05).

When the intestinal mucosa is damaged, bacterial translocation can lead to the occurrence of intestinal infection, and early postoperative abdominal surgery can lead to the occurrence of intestinal bacterial translocation. The use of antibiotics can reduce bacterial infection, improve intestinal mucosal permeability, and promote the recovery of the body.