To evaluate the value of controlled low central venous pressure（CLCVP）combined with intraoperative ultrasound in laparoscopic resection of large liver cancer.

The clinical data of 112 patients with intraoperative ultrasound-assisted laparoscopic resection of large hepatocellular carcinoma from January 2015 to December 2017 were retrospectively analyzed. According to whether CLCVP was performed or not，they were divided into combination group（n=54）and ultrasound group（n=58）. The CVP of the combined group was maintained at less than 5cmH₂O by means of fluid restriction and vasodilator drugs，while the CVP of the ultrasound group was maintained at 5~12 cmH₂O. Data were processed by SPSS 24.0 software，intraoperative and postoperative indicators，liver and kidney function levels and other measurement data were expressed as（

The blood flow blocking time，intraoperative blood loss，operation time，drainage tube removal time and hospital stay in the combined group were significantly reduced compared with those in the ultrasound group（P<0.05），and the postoperative liver function damage was significantly lower than that in the ultrasound group（P<0.05）. There were no significant differences in tumor resection margin，tumor diameter，postoperative ventilation time，postoperative complications，and postoperative renal function between the two groups（P>0.05）. Kaplan-Meier method was used to analyze the follow-up data of patients within 5 years，and the results showed that there was no significant difference in the postoperative survival rate between the two groups（P>0.05）. Conclusion CLCVP combined with intraoperative ultrasound can help patients with large liver cancer surgically remove the tumor，reduce intraoperative liver function damage and shorten the length of hospital stay，which is worthy of clinical promotion and application.