To investigate the Clinical effect of different approaches in laparoscopic colorectal cancer surgery.

116 cases of colorectal cancer patients in our hospital from January 2018 to December 2020 were selected. The patients were divided into control group and study group according to random number table，each of 58 cases. Laparoscopic radical resection of colorectal cancer was performed in both groups，the control group was treated with traditional lateral approach，and the study group was treated with “four-step” technique through the middle approach. The data were processed by SPSS 22.0. The measurement data of perioperative related indicators were expressed by（

Compared with the control group，the perioperative operation time，intraoperative blood loss，postoperative exhaust time，recovery of fluid diet time and postoperative hospital stay of the study group were significantly reduced，and the number of lymph node dissection was significantly increased，with statistically significant differences（P<0.05）. The incidence of total complications in the study group was significantly lower than that in the control group（6.9% vs.20.7%，P<0.05）. Postoperative follow-up was 5~41 months，with a median follow-up of 28 months. There was no statistical significance in cumulative overall survival and disease-free survival between the two groups（P>0.05）.

The application of the middle approach “four-step method” in the separation of splenic curvature of colon in laparoscopic radical resection of colorectal cancer not only has the advantages of short operation time，less intraoperative bleeding，quick postoperative recovery and more thorough lymph node dissection，but also can effectively reduce the risk of complications，and the safety of the operation is higher.