To evaluate the safety of the clinical application of laparoscopic radical resection of right colonic carcinoma taken from natural cavity.

Retrospectively analyzed the data of 90 patients with right colon cancer who underwent laparoscopic radical resection in our hospital and The First Affiliated Hospital of Chongqing Medical University from September 2017 to December 2019, and divided them into NOSES group and TLC group according to different surgical methods, of which 42 Routine laparoscopic radical resection of right colonic cancer (NOSES group) was performed through the natural cavity, and 48 patients underwent traditional laparoscopic colorectal cancer resection (TLC group). SPSS 22.00 statistical software was used for data analysis. Measurement data such as perioperative indicators were represented by (±s) and independent t-test was used; Tumor cytology test results and postoperative complication rate were measured by χ² test. Rank sum test was used for the data of pathological stage and histological grade. Overall and disease-free survival rates were analyzed by Kaplan-Meier survival analysis. P<0.05 was statistically significant.

The positive rate of tumor cells in the peritoneal lavage fluid of the two groups was 0%, and the positive rate of bacterial culture in the NOSES group was 30.9% (13/42) than that in the TLC group was 31.2% (15/48), the difference was not statistically significant (P=0.976); phase Compared with the TLC group, the NOSES group had a longer operation time, shorter anal exhaust time, postoperative hospital stay, and less intraoperative blood loss.The difference was statistically significant (P<0.05); The 3-year survival rate is 90.5%, and the disease-free survival rate is 88.1% in the NOSES group, In TLC group, the 3-year overall survival rate was 93.8% and the disease-free survival rate was 87.5%.The differences were not statistically significant (P>0.05). there was no statistical difference in pelvic floor function between the two groups before and after surgery (P>0.05).

Laparoscopic radical resection of the right colonic carcinoma taken through the natural cavity has good short-term curative effect and does not affect the patient’s pelvic floor function. It is clinically safe and feasible.