Abstract:
Objective To analyze the efficacy and safety of combined therapy of multiple operation for T1a stage gallbladder cancer.
Methods The clinical data of 80 patients with stage T1a gallbladder cancer treated in our hospital from January 2016 to January 2019 were retrospectively analyzed. 32 patients who underwent laparoscopic cholecystectomy + lymphadenectomy + radiofrequency ablation were included in the laparoscopy group, 48 patients who underwent open cholecystectomy + lymphadenectomy + radiofrequency ablation were included in the open group. SPSS 21.0 software package was used to analyze the entire group of data. Surgical curative effect, postoperative complication frequency (n), rate (%) were described, and χ2 test was used; surgical-related indicators, and the quality of life questionnaire (QOL) score for Chinese cancer patients were used (±s) description, and compared with t test, P<0.05 was considered statistically significant.
Results The total effective rate (93.8%) in the laparoscopic group was slightly higher than that in the open group (89.6%). The overall incidence of postoperative complications (6.3%) was slightly lower than that in the open group (20.8%), but the differences were not statistically significant (P>0.05); the operation time, postoperative exhaust time, and postoperative hospital stay in the laparoscopic group were shorter than those in the open group, and the intraoperative blood loss was less than that in the open group (P<0.05). In the laparoscopic group, the appetite, mental, pain, fatigue, daily activities, and family comprehension scores of the QOL scale at 6 months after operation were higher than those of the open group (P<0.05).
Conclusion Bothe of the combined therapy of multiple operation for T1a stage gallbladder cancer is quite effective, but compared with open cholecystectomy + lymph dissection + radiofrequency ablation, laparoscopic cholecystectomy + lymph dissection + radiofrequency ablation has less trauma, lower bleeding, which postoperative complications are fewer and more conducive to improving quality of life.
Key words:
T1a stage gallbladder cancer,
Cholecystectomy, laparoscopic,
Lymph node excision,
Postoperative complications,
Quality of life,
Radiofrequency ablation
Yu Zhang, Zhenwen Liu, Xiaofeng Zhang, Zhijie Li, Hongbo Wang, Daping Xin. Efficacy and safety analysis of combined therapy of multiple operation for T1a stage gallbladder cancer[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2020, 14(03): 233-236.