To compare the clinical effects of laparoscopic radical resection of colorectal cancer (LCR) and laparoscopic transluminal resection of colorectal cancer specimens (NOSE) in the treatment of colorectal cancer.

The data of patients with colorectal cancer who underwent surgical treatment from April 2013 to April 2018 were retrospectively analyzed. The patients were divided into NOSE group (63 cases underwent laparoscopic NOSE) and LCR group (63 cases underwent laparoscopic LCR). The software SPSS 19.0 was used for statistical analysis. Rehabilitation index comparison, oxidative stress index and inflammatory factors were described by (±s), independent t test, and incidence of complications by χ² test. The difference was statistically significant with P<0.05.

Compared with LCR group, the recovery indexes (exhaust time and hospitalization time) of NOSE group were significantly shorter (P < 0.05), oxidative stress indexes (MDA, SOD) were significantly higher (P<0.05) and SOD was significantly lower (P<0.05), but the SOD and MDA of NOSE group were lower than those of LCR group. Comparisons of CRP, TNF-a and IL-6 showed that the increase of NOSE group was lower than that of LCR group, and the incidence of complications in NOSE group was lower than that in LCR group (6.4% vs.19.1%), P<0.05.

Compared with traditional laparoscopic LCR, laparoscopic NOSE for colorectal cancer is effective in improving oxidative stress and inflammatory response, reducing the incidence of postoperative complications and facilitating rapid recovery.