腹腔镜胰十二指肠切除术（LPD）是治疗胰头及壶腹部周围病变的复杂微创手术，具有创伤小、恢复快等优势，但术后并发症发生率仍较高。本文旨在探讨LPD术后主要并发症的发生机制、临床表现及处理策略，总结针对性的预防与治疗措施，为临床实践提供参考，以提升手术安全性及患者预后。

Laparoscopic pancreaticoduodenectomy (LPD) is a complex minimally invasive surgery for treating periampullary and pancreatic head lesions. Although it has advantages such as less trauma and faster recovery, the incidence of postoperative complications is relatively high, which seriously affects the prognosis of patients. From a commentary perspective, this article analyzes the pathogenesis, clinical characteristics and treatment strategies of major complications such as pancreatic fistula, bleeding, biliary fistula and delayed gastric emptying after LPD, and discusses the controversies and progress in current diagnosis and treatment combined with 15 Chinese and English literatures,so as to provide reference for clinical practice.